To evaluate the duration of favourable effects of coronary artery bypass (CAB) on exercise-induced angina (A), 58 patients: 13 with single 21 with double and 24 with triple vessel disease, were studied. All patients underwent CAB for stable angina on effort. Patients underwent exercise testing (ET) before surgery at one, two and three years. Heart rate peak (HR), HR x systolic blood pressure peak (DP), work load (W), exercise-induced ST segment depression (ST) and incidence of A were evaluated; the results of ET before surgery were compared with those found after CAB. Our findings show that HR, DP, W and ST were significantly improved by surgery for at least 3 years. The lowest incidence of A was found at one year ET (20.6%), while it increased at two years (27,5%) and three years ET (37.9%). Most patients with A had angiographic evidence of left ventricular abnormal wall motion and ec-graphic signs of previous myocardial infarction. Our data indicate that serial exercise testing can objectively monitor the results of CAB. Most patients show an improved exercise tolerance for up to 3 years after CAB. Some patients, with more extensive CAD, showed a progressive deterioration of the clinical pattern and a decrease of the exercise tolerance.
Download full-text PDF |
Source |
---|
Invest Ophthalmol Vis Sci
January 2025
Institute of Ophthalmology, School of Medicine, Jinan University, Guangzhou, China.
Purpose: To investigate the therapeutic efficacy of BEZ235, a dual PI3K/mTOR inhibitor, in suppressing pathological neovascularization in an oxygen-induced retinopathy (OIR) mouse model and explore the role of cyclin D1 in endothelial cell cycle regulation.
Methods: Single-cell RNA sequencing was performed to analyze gene expression and cell-cycle alterations in retinal endothelial cells under normoxic and OIR conditions. The effects of BEZ235 on human umbilical vein endothelial cells (HUVECs) and human retinal microvascular endothelial cells (HRMECs) were evaluated by assessing cell viability, cell-cycle progression, proliferation, migration, and tube formation.
JAMA Netw Open
January 2025
Healthcare Transformation Institute, Department of Medical Ethics and Health Policy, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.
Importance: Adherence to glucagon-like peptide-1 receptor agonists (GLP-1 RAs) is important for their effectiveness. Discontinuation and reinitiation patterns are not well understood.
Objective: To describe rates of and factors associated with discontinuation and subsequent reinitiation of GLP-1 RAs among adults with overweight or obesity.
Sports Med
January 2025
Department of Sport Science and Physical Education, Faculty of Health and Sport Sciences, University of Agder, Kristiansand, Norway.
Background: Endurance athletes tend to accumulate large training volumes, the majority of which are performed at a low intensity and a smaller portion at moderate and high intensity. However, different training intensity distributions (TID) are employed to maximize physiological and performance adaptations.
Objective: The objective of this study was to conduct a systematic review and network meta-analysis of individual participant data to compare the effect of different TID models on maximal oxygen uptake (VO) and time-trial (TT) performance in endurance-trained athletes.
Med Biol Eng Comput
January 2025
Faculty of Computing, Harbin Institute of Technology, Harbin, 150001, China.
The lumen centerline of the coronary artery allows vessel reconstruction used to detect stenoses and plaques. Discrete-action-based centerline extraction methods suffer from artifacts and plaques. This study aimed to develop a continuous-action-based method which performs more effectively in cases involving artifacts or plaques.
View Article and Find Full Text PDFPediatr Radiol
January 2025
Department of Gastroenterology, Brigham and Women's Hospital, Boston, MA, USA.
Background: Optimization of localizer radiograph and bolus tracking doses is necessary, as their dose proportion may increase with a decreasing diagnostic scan dose in pediatric cardiothoracic computed tomography (CT).
Objective: To evaluate the radiation dose proportions of the localizer radiograph and bolus tracking in low-dose pediatric cardiothoracic CT.
Materials And Methods: For low-dose pediatric cardiothoracic CT, a posteroanterior localizer radiograph was acquired with 80 kV, and 35 mA or 20 mA in 852 infants (age<1 year).
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!