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Obesity cardiomyopathy could contribute to sudden cardiac death: a Japanese epidemiological morphological study.
Cardiovasc Diabetol
October 2024
Department of Diagnostic Pathology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita, 879-5593, Japan.
Background: We aimed to clarify the existence and pathological features of obesity cardiomyopathy (OCM) in Japan using our series of autopsy cases.
Methods: In this retrospective autopsy study, OCM was defined as cardiac hypertrophy (≥ 400 g in men, ≥ 320 g in women) of unknown aetiology in individuals with obesity (body mass index [BMI] ≥ 25 kg/m according to the Japanese definition of obesity). We compared cases of OCM with those with obesity without cardiac hypertrophy (OB) and normal weight without cardiac hypertrophy (normal control).
Finerenone in Patients With a Recent Worsening Heart Failure Event: The FINEARTS-HF Trial.
J Am Coll Cardiol
January 2025
Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Article Synopsis
- Patients with heart failure (HF) are at an increased risk of hospital readmission and mortality, particularly following a recent worsening heart failure (WHF) event.
- The FINEARTS-HF trial investigated the impact of the drug finerenone on cardiovascular events in HF patients, focusing on their WHF history and timing of treatment initiation.
- Results showed that those treated with finerenone shortly after a WHF event (within 7 days) had a significantly reduced risk of cardiovascular issues compared to the placebo group, indicating timeliness of treatment may influence effectiveness.
Better Respiratory Function in Heart Failure Patients With Use of Central-Acting Therapeutics.
CJC Open
May 2024
Peter Munk Cardiac Centre, Division of Cardiology, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.
Article Synopsis
- Diaphragm atrophy can worsen breathing issues in heart failure patients, possibly linked to medication effects on the brain.
- A study of 624 heart failure patients examined the respiratory benefits of central-acting vs peripheral-acting drugs through cardiopulmonary exercise tests (CPET).
- Results showed that patients on central-acting drugs had improved respiratory function and potentially fewer adverse outcomes, highlighting their effectiveness in managing heart failure symptoms.
A Longer Life or a Quality Death? A Discrete Choice Experiment to Estimate the Relative Importance of Different Aspects of End-of-Life Care in the United Kingdom.
MDM Policy Pract
May 2024
Health Economics Group, University of East Anglia, Norwich, UK.
Unlabelled: Advocates argue that end-of-life (EOL) care is systematically disadvantaged by the quality-adjusted life-year (QALY) framework. By definition, EOL care is short duration and not primarily intended to extend survival; therefore, it may be inappropriate to value a time element. The QALY also neglects nonhealth dimensions such as dignity, control, and family relations, which may be more important at EOL.
View Article and Find Full Text PDFContinuous palliative sedation until death: a qualitative study of palliative care clinicians' experiences.
BMC Palliat Care
April 2024
Réseau Québécois de Recherche en Soins Palliatifs et de fin de vie, Québec, Canada.
Background: The practice of continuous palliative sedation until death is the subject of much medical and ethical debate, which is reflected in the inconsistency that persists in the literature regarding the definition and indications of palliative sedation.
Aim: This study aims to gain a better understanding of palliative care clinicians' experiences with continuous palliative sedation.
Design: We conducted a qualitative study based on focus group discussions.
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