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Molecular characterization and sub-retinal transplantation of hypoimmunogenic human retinal sheets in a minipig model of severe photoreceptor degeneration.
Development
December 2024
Stem Cell and Developmental Biology Laboratory, Hôpital Maisonneuve-Rosemont, 5690 Boul. Rosemont, Montreal, QC H1T 2H2, Canada.
Article Synopsis
- * Researchers created retinal sheets (RSs) using induced pluripotent stem cells, which contained precursors capable of developing into mature cone cells, mimicking the development of the human retina.
- * In a test on pigs with retinal degeneration, these grafted RSs integrated into the retina and demonstrated some function, indicating potential for future therapeutic applications despite ongoing challenges.
Behavioral decline in Shank3 mice during early adulthood parallels cerebellar granule cell glutamatergic synaptic changes.
Mol Autism
December 2024
Department of Pharmacology, Southern Illinois University - School of Medicine, Springfield, IL, 62702, USA.
Article Synopsis
- The SHANK3 gene is linked to autism spectrum disorder (ASD) and is disrupted in Phelan-McDermid syndrome (PMS), which can worsen ASD symptoms; the study explores how Shank3 affects behavioral and cerebellar function in mice.
- Researchers examined various behavioral changes in Shank3 knockout mice at juvenile and adult stages, finding that deletion of Shank3 leads to motor deficits, increased anxiety, and repetitive behaviors, with effects becoming more severe in adults.
- Immunostaining and electrophysiology revealed Shank3 expression in cerebellar granule cells and a connection between behavioral deterioration and changes in synaptic activity, suggesting that age exacerbates behavioral issues due to alterations in cerebellar
Spontaneous ependymoma in a free-ranging juvenile black-horned capuchin (Sapajus nigritus).
J Comp Pathol
November 2024
Veterinary Pathology Laboratory, Department of Veterinary Sciences, Federal University of Paraná, Palotina, Paraná, Brazil.
A young free-ranging black-horned capuchin (Sapajus nigritus) with a history of ataxia, anisocoria, diminished threat and pupil reflexes and increased cranial circumference was referred for evaluation to the Medicine and Wildlife Conservation Section, Federal University of Paraná, Paraná, Brazil. Due to the clinical presentation and radiographic findings of hydrocephalus, euthanasia was performed. Necropsy revealed a dark red mass (1.
View Article and Find Full Text PDFGuinea pig spermatozoa adhesion to an immobilized fibronectin matrix alters their physiology and increases their survival†.
Biol Reprod
December 2024
Dept. of Cell Biology Center of Research and Advanced Studies of the National Polytechnic Institute, Mexico city, Mexico Av. Instituto Politecnico Nacional 2508, CP 07360.
Isthmus is the region of the oviduct considered a reservoir for spermatozoa, where they are retained and released synchronously with ovulation. Integrins mediate this interaction, and it is suggested that they regulate the viability and capacitation of spermatozoa. Spermatozoa retained in the oviductal epithelial cells show specific characteristics: normal morphology, intact acrosome and plasma membrane, no DNA fragmentation, and low levels of intracellular Ca2+, and protein phosphorylation at Tyr.
View Article and Find Full Text PDFBehavioral regression in shank3 mice during early adulthood corresponds to cerebellar granule cell glutamatergic synaptic changes.
Res Sq
September 2024
Department of Pharmacology, Southern Illinois University - School of Medicine, Springfield, IL 62702.
Background: , a gene encoding a synaptic scaffolding protein, is implicated in autism spectrum disorder (ASD) and is disrupted in Phelan-McDermid syndrome (PMS). Despite evidence of regression or worsening of ASD-like symptoms in individuals with PMS, the underlying mechanisms remain unclear. Although is highly expressed in the cerebellar cortical granule cells, its role in cerebellar function and contribution to behavioral deficits in ASD models are unknown.
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