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Determining the Exposure Routes and Risk Assessment of Isocyanates in Indoor Environments.
Arch Environ Contam Toxicol
November 2024
Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.
Isocyanates are used as raw materials for polyurethane foams, paints, and building materials. The isocyanates can cause acute adverse health effects such as irritation of the respiratory tract, skin, and eyes, and induce asthma and sick house syndrome. However, investigations into the potential sources and risk assessments of indoor isocyanates are limited.
View Article and Find Full Text PDFThe Potential of Glucosinolates and Their Hydrolysis Products as Inhibitors of Cytokine Storms.
Molecules
October 2024
National Agrobiodiversity Center, National Institute of Agricultural Sciences, Rural Development Administration, Jeonju 54874, Republic of Korea.
A cytokine storm is an intense inflammatory response characterized by the overproduction of proinflammatory cytokines, resulting in tissue damage, and organ dysfunction. Cytokines play a crucial role in various conditions, such as coronavirus disease, in which the immune system becomes overactive and releases excessive levels of cytokines, including interleukins, tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ). This anomalous response often leads to acute respiratory distress syndrome (ARDS), disseminated intravascular coagulation (DIC), and multiple organ injury (MOI).
View Article and Find Full Text PDFExposure to toluene diisocyanate induces dysbiosis of gut-lung homeostasis: Involvement of gut microbiota.
Environ Pollut
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Clinical Medical School, Guizhou Medical University, Guiyang, Guizhou, 561113, China.
Toluene diisocyanate (TDI) is a major industrial compound that induces occupational asthma with steroid-resistant properties. Recent studies suggest that the gastrointestinal tract may be an effective target for the treatment of respiratory diseases. However, the alterations of the gut-lung axis in TDI-induced asthma remain unexplored.
View Article and Find Full Text PDFOccupational respiratory disease in Eastern Slovakia between 1990-2021: a shift from agriculture to industrial manufacturing.
Cent Eur J Public Health
September 2024
Department of Occupational Medicine and Clinical Toxicology, Medical Faculty, Pavol Jozef Safarik University and L. Pasteur University Hospital, Kosice, Slovak Republic.
Article Synopsis
- The study looked at allergic breathing problems for people working in jobs like farming, food production, and textiles in Eastern Slovakia from 1990 to 2021.
- It found that the number of cases, especially occupational asthma (OA), has gone down over the years, particularly in farming jobs.
- Now, more people are getting these allergic issues from working with metalworking fluids (MWFs) in industrial manufacturing instead of from farming.
PEITC Induces DNA Damage and Inhibits DNA Repair-Associated Proteins in Human Retinoblastoma Cells In Vitro.
Environ Toxicol
December 2024
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan.
Phenethyl isothiocyanate (PEITC), a natural product, exists in biological activities, including anticancer activity in many human cancer cells. No information shows that PEITC affects DNA damage in human retinoblastoma (RB) cells in vitro. In this study, the aim of experiments was to determine whether PEITC decreased total viable cell number or not by inducing protein expressions involved in DNA damage and repair in Y79 RB cells in vitro.
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