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Cell culture evidence for neuronal degeneration in amyotrophic lateral sclerosis being linked to glutamate AMPA/kainate receptors.
Lancet
January 1993
Cell Neurobiology Unit, Faculty of Medicine, Limoges, France.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder affecting motor neurons. Glutamate, a potent central-nervous-system toxin, has been proposed as one possible factor in this motoneuron disease. Serum from patients with ALS is known to be toxic when added to neurons in culture.
View Article and Find Full Text PDFI have reviewed information pertaining to the acidic amino acid analogs of glutamate that have neurotoxic (excitotoxic) activity and pointed out that kainate is the most potent excitotoxin that has been subjected to intensive investigation. Although there is very little published evidence pertaining to domoate neurotoxicity, all available evidence supports the conclusion that the neuroactive properties of domoate are mediated through kainate receptors. Preliminary evidence that domoate powerfully induces a kainate-like seizure-brain damage syndrome in experimental animals further supports involvement of kainate receptors in domoate neurotoxicity.
View Article and Find Full Text PDFEndogenous inhibitor of [3H]kainate binding to synaptic membrane in rat brain.
J Biochem
December 1986
An understanding of the mechanism of kainic acid toxicity to neurons could provide important clues to pathogenesis of Huntington's chorea. The existence of high-affinity binding sites for kainate, a foreign compound, is suggestive of the existence of kainate-like substances in the brain. In addition to such neurotoxic kainate-like substances, and endogenous inhibitor of kainate binding may also exist in the brain to allow the synaptic function to operate normally.
View Article and Find Full Text PDFFolic acid has been injected unilaterally into the amygdaloid complex of awake chronically implanted rats, or in rats under anaesthesia. Clinical, electrographic, and metabolic changes (estimated by means of the 2-deoxyglucose method) have been studied in relation to subsequently demonstrated neuropathology using Fink-Heimer and Nissl stains. The observations are compared to the corresponding effects of intra-amygdaloid application of kainic acid.
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