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The role of alpha1-antitrypsin in total hip replacement: a pilot study.
Hip Int
June 2010
Department of Trauma and Orthopaedics, Royal Devon and Exeter Hospital, Exeter, UK.
Background: Lungs exposed to particulate debris may be damaged by proteolytic enzymes during phagocytosis. Damage is worse if patients are deficient in alpha1-antitrypsin (A1AT), which helps neutralise these enzymes. We investigated the possibility that A1AT deficiency contributes to aseptic loosening following total hip replacement (THR) when wear particles are phagocytosed.
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