The synthesis and the trichomonacidal activity of some 4-substituted 2-imidazolylquinazoline derivatives are described. The new compounds were highly active against metronidazole-sensitive and metronidazole-resistant strains of trichomonads. This was demonstrated in vitro as well as in various trichomoniasis models in mice and rats after oral treatment.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Vaginal Tritrichomonas foetus infection in mice as an in vivo model for drug development against Trichomonas vaginalis.
PLoS One
October 2024
Department of Medicine, University of California San Diego, La Jolla, California, United States of America.
Article Synopsis
- Trichomonas vaginalis causes trichomoniasis, a widespread STD that affects over a hundred million people, and resistance to common treatments like metronidazole is increasing.
- The study explored using Tritrichomonas foetus, a related parasite, as a better animal model for testing new treatments since it caused reliable infections in mice, unlike T. vaginalis.
- Findings showed that while some drugs had similar effectiveness on both parasites, proteasome inhibitors were less effective on T. foetus, suggesting the need for targeted drug development and further understanding of genetic differences between the two organisms.
Molecular detection and characterization of Trichomonas gallinae isolated from ornamental birds in Tehran, Iran.
Parasitol Res
September 2024
Department of Parasitology, Faculty of Veterinary Medicine, Islamic Azad University, Karaj, Iran.
Article Synopsis
- Trichomonas gallinae is a common protozoan parasite affecting birds and causing avian trichomonosis, with this study focusing on its prevalence and genetic diversity in birds in Tehran, Iran.
- Out of 100 birds examined, 12% were infected: 23.3% of feral pigeons, 7.5% of budgerigars, and 6.66% of finches were found to have the parasite.
- Genetic analysis identified two similar sequences from the ITS2 region and revealed three distinct subtypes through the Fe-hydrogenase gene, suggesting a more complex population structure of T. gallinae and insights into how it adapts to different bird hosts.
Differential Drug Susceptibility across Trichomonasvirus Species Allows for Generation of Varied Isogenic Clones of .
Pathogens
August 2024
Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.
Article Synopsis
- Trichomonas vaginalis (Tvag) is a sexually transmitted pathogen linked to five strains of Trichomonas vaginalis viruses (TVVs), which are typically passed directly from mother to daughter cells without an extracellular phase in their lifecycle.* -
- A nucleoside analog called 2'-C-methylcytidine (2CMC) has been found effective in clearing infections from various TVV strains, including TVV1, TVV2, and TVV3, and newly confirmed to also clear TVV4 and TVV5.* -
- The study revealed differences in drug susceptibility among TVV species, allowing for the creation of genetically similar Tvag clones with various TVV combinations, which may
(Tvag) is a sexually transmitted human pathogen that is commonly infected with strains of one or more of five known species of Trichomonas vaginalis viruses (TVVs), members of genus . TVVs are thought not to have an extracellular phase to their lifecycle and instead to be transmitted vertically from mother to daughter cells. As a result, generation of isogenic virus-positive and virus-negative sets of Tvag clones has been a major barrier to study interactions between TVVs and their host.
View Article and Find Full Text PDFComparative genomics between and : CAZymes and candidate virulence factors.
Front Microbiol
July 2024
Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
Introduction: The oral trichomonad is increasingly appreciated as a likely contributor to periodontitis, a chronic inflammatory disease induced by dysbiotic microbiota, in humans and domestic animals and is strongly associated with its worst prognosis. Our current understanding of the molecular basis of interactions with host cells and the microbiota of the oral cavity are still rather limited. One laboratory strain of T.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!