Acute menorrhagia in adolescence is a much underestimated clinical problem, often requiring urgent medical intervention. In a 9-year case review between January, 1971, and January, 1980, we looked at all admissions to a children's hospital for acute menorrhagia, where genital tract pathology had been excluded. A primary coagulation disorder was found in almost 20% of these 59 patients. One quarter of those with severe menorrhagia (hemoglobin less than 10 gm/100 ml), one third of those requiring transfusion, and one half of those presenting at menarche had such an underlying disorder. Therefore, proper screening and therapy are essential in all girls with menorrhagia. Conventional methods of hormonal control are only partially effective in these special cases.
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http://dx.doi.org/10.1016/0002-9378(81)90009-0 | DOI Listing |
Hematology Am Soc Hematol Educ Program
December 2024
Division of Hematopathology, Mayo Clinic, Rochester, MN.
von Willebrand disease (VWD) is a common inherited bleeding disorder caused by von Willebrand factor (VWF) deficiency and is an important cause of heavy menstrual bleeding in young patients. A clinical evaluation using standardized bleeding scores helps determine when screening hemostatic testing is indicated by identifying patients with a moderate or high probability of an inherited bleeding disorder. The diagnosis of VWD is made when VWF levels are under 30 IU/dL or between 30 and 50 IU/dL when there is a positive bleeding history.
View Article and Find Full Text PDFCase Rep Obstet Gynecol
October 2024
Department of Obstetrics & Gynecology, University of Arizona College of Medicine, Phoenix, Arizona, USA.
SAGE Open Med Case Rep
October 2024
Department of Obstetrics and Gynaecology, Irrua Specialist Teaching Hospital, Irrua, Nigeria.
Int J Ophthalmol
September 2024
Department of Ophthalmology, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan, China.
Cureus
March 2024
Internal Medicine, Lakeland Regional Health Medical Center, Lakeland, USA.
This report of two cases confronts the longstanding perception of Sickle Cell Trait (SCT) as a clinically benign condition, highlighting its complex and severe clinical manifestations, particularly in the context of blood loss anemia and vaso-occlusive crises (VOCs). The hallmark of sickle cell disease is the severe pain caused by acute vaso-occlusion of the microvasculature that leads to bone marrow infarction. We report two cases of patients with SCT and severe anemia in the setting of blood loss secondary to uterine fibroids subsequently causing VOCs with likely bone sequestration.
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