AI Article Synopsis
- The W3/25+ T cell subset in rats is identified using a specific antibody and isolated with FACS (Fluorescence-Activated Cell Sorting).
- This W3/25+ T cell subset shows significant cell proliferation in an in vitro mixed lymphocyte culture (MLC).
- It acts as an amplifier for the W3/25- T cell subset, enhancing the production of cytotoxic effector cells that target alloantigens.
Article Abstract
The W3/25+ T cell subset in rats, defined by a xenogeneic monoclonal antibody and separated by using the FACS, was demonstrated to be the proliferating cell type in the in vitro MLC and to provide an amplifier function for the W3/25- T cell subset in the generation of cytotoxic effector cells to alloantigenic targets.
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