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Stress-induced metabolic and immunological changes in the body are analyzed. Alterations in sympathetic-adrenal and kinin systems are noted. Attention is paid to immune system as well.
View Article and Find Full Text PDFThe sympathetic-adrenal and kallikrein-kinin systems were studied in 225 patients with various coronary heart diseases before and after therapy with lipoic acid (150 mg/day), tocopherol (100 mg/day), anaprilin (40 mg/day), prodectin (750 mg/day) or their combination. Myocardial and adrenal catecholamine levels were measured in experiments on animals exposed to emotional pain stress. Their levels were found to be affected by lipoic acid, tocopherol, obsidan or their combinations in the same doses, taking into account species specificity.
View Article and Find Full Text PDFA comparative study is presented of some components of the kinin, sympathetic-adrenal system and plasma prostacyclin in 296 patients with active rheumatism of different activity grades and disorders of the cardiac rhythm. Data were obtained on the activation of the sympathetic-adrenal and kinin system in rheumocarditis with disorders of the cardiac rhythm. A relationship was established between the components of these systems.
View Article and Find Full Text PDFApplication of kainic acid (KA) to the rostral ventral surface of the medulla oblongata (RVM) produced an increase in mean arterial pressure, accompanied by a decrease in substance P-like immunoreactivity in both spinal cord and medulla oblongata and an elevation of plasma adrenaline (AD) and noradrenaline (NA) content. There were no significant changes in the amounts of AD and NA in other areas of the central nervous system. These responses were effectively abolished by pre-intrathecal injection of D-pro2, D-phe7 or D-Trp8-SP.
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