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Detection of homing-in of stem cells labeled with technetium-99m hexamethylpropyleneamine oxime in infarcted myocardium after intracoronary injection.
Indian J Nucl Med
October 2014
Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India.
Bone marrow stem cells having myogenic potential are promising candidates for various cell-based therapies for myocardial disease. We present here images showing homing of technetium-99m (Tc-99m) hexamethylpropyleneamine oxime (HMPAO) labeled stem cells in the infarcted myocardium from a pilot study conducted to radio-label part of the stem cells in patients enrolled in a stem cell clinical trial for recent myocardial infarction.
View Article and Find Full Text PDFClinical feasibility study to detect angiogenesis following bone marrow stem cell transplantation in chronic ischaemic heart failure.
Nucl Med Commun
August 2014
aDepartment of Cardiology, The London Chest Hospital bInstitute of Nuclear Medicine, University College London Hospital cBritish Heart Foundation Laboratories, University College London, London, UK dSection of Cardiovascular Medicine, School of Medicine, Yale University, New Haven, Connecticut, USA eDepartment of Nuclear Medicine, Karolinska University Hospital, Huddinge, Sweden fCentre for Medical Radiation Physics, University of Wollongong, Wollongong, New South Wales, Australia.
Background: Bone marrow stem cell (BMSC) therapy for cardiovascular disease has shown considerable preclinical and clinical promise, but there remains a need for mechanistic studies to help bridge the transition from bench to bedside. We have designed a substudy to our REGENERATE-IHD trial (ClinicalTrial.gov Identifier: NCT00747708) to assess the feasibility of a novel imaging technique to detect angiogenesis following BMSC therapy.
View Article and Find Full Text PDFStromal cell-derived factor-1 retention and cardioprotection for ischemic myocardium.
Circ Heart Fail
July 2011
Harvard Stem Cell Institute, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA.
Background: Stromal cell-derived factor-1 (SDF-1) is a chemoattractant of stem/progenitor cells, and several studies have shown that SDF-1 may improve ventricular function after infarction. SDF-1 is cleaved by proteases including matrix metalloproteinase-2 (MMP-2) and CD26/dipeptidylpeptidase-4 (DPP-4), which are activated in injured tissues.
Methods And Results: We investigated the biodistribution and functional roles of SDF-1 in experimental ischemia/reperfusion injury in rats.
Autologous bone-marrow mononuclear cell transplantation after acute myocardial infarction: comparison of two delivery techniques.
Cell Transplant
July 2009
Teaching and Research Center of Pró-Cardíaco/PROCEP, Rio de Janeiro, Brazil.
The objective of this study was to investigate safety and feasibility of autologous bone marrow mononuclear cells (BMMNC) transplantation in ST elevation myocardial infarction (STEMI), comparing anterograde intracoronary artery (ICA) delivery with retrograde intracoronary vein (ICV) approach. An open labeled, randomized controlled trial of 30 patients admitted with STEMI was used. Patients were enrolled if they 1) were successfully reperfused within 24 h from symptoms onset and 2) had infarct size larger than 10% of the left ventricle (LV).
View Article and Find Full Text PDFPilot trial on determinants of progenitor cell recruitment to the infarcted human myocardium.
Circulation
September 2008
Department of Medicine III, Division of Cardiology, JW Goethe University Frankfurt, Frankfurt am Main, Germany.
Background: Clinical trials indicate a beneficial effect of intracoronary infusion of progenitor cells on myocardial function in patients with ischemic heart disease. The extent and potential determinants of proangiogenic progenitor cell homing into the damaged myocardium after intracoronary infusion and the underlying mechanisms are still unknown.
Method And Results: Circulating proangiogenic progenitor cells isolated from peripheral blood and cultivated for 3 days were labeled with radioactive indium oxine ((111)In-oxine).
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