Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Marine natural products as a source of novel anticancer drugs: an updated review (2019-2023).
Nat Prod Bioprospect
January 2025
International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang, 212013, China.
Marine natural products have long been recognized as a vast and diverse source of bioactive compounds with potential therapeutic applications, particularly in oncology. This review provides an updated overview of the significant advances made in the discovery and development of marine-derived anticancer drugs between 2019 and 2023. With a focus on recent research findings, the review explores the rich biodiversity of marine organisms, including sponges, corals, algae, and microorganisms, which have yielded numerous compounds exhibiting promising anticancer properties.
View Article and Find Full Text PDFUncommon Diterpenoids with Diverse Frameworks from the South China Sea Sponge and Their Anti-inflammatory Activities.
J Org Chem
January 2025
School of Medicine, Shanghai University, 99 Shangda Road, BaoShan District, Shanghai 200444, China.
Uncommon diterpenoids with diverse frameworks, including one unexpected iodinated oxa-6/6/6/6-tetracyclic diterpene () and its monobrominated 6/6/6-tricyclic analogue () and one novel isodolastane-type diterpene featuring an unusual aromatic 5/7/6-tricyclic ring system () as well as a related known dolastane-type diterpenoid (), were isolated from the South China Sea sponge . Their structures, including absolute configurations, were established by extensive spectroscopic data analysis, X-ray diffraction analysis, and quantum mechanical-nuclear magnetic resonance and time-dependent density functional theory/electronic circular dichroism calculations. A plausible biosynthetic pathway of new compounds - was proposed.
View Article and Find Full Text PDFHuman Activity as a Growing Threat to Marine Ecosystems: Plastic and Temperature Effects on the Sponge .
Toxics
January 2025
Research Group in Community Nutrition and Oxidative Stress (NUCOX), University of Balearic Islands, 07122 Palma de Mallorca, Spain.
Human activities increasingly threaten marine ecosystems through rising waste and temperatures. This study investigated the role of plastics as vectors for bacteria and the effects of temperature on the marine sponge . Samples of plastics and sponges were collected during July, August (high-temperature period), and November (lower-temperature period).
View Article and Find Full Text PDFExploring Antibacterial Properties of Marine Sponge-Derived Natural Compounds: A Systematic Review.
Mar Drugs
January 2025
Institute of Pharmaceutical Sciences of Western Switzerland (ISPSO), University of Geneva, 1206 Geneva, Switzerland.
The rise in multidrug-resistant (MDR) bacteria has prompted extensive research into antibacterial compounds, as these resistant strains compromise current treatments. This resistance leads to prolonged hospitalization, increased mortality rates, and higher healthcare costs. To address this challenge, the pharmaceutical industry is increasingly exploring natural products, particularly those of marine origin, as promising candidates for antimicrobial drugs.
View Article and Find Full Text PDFBioactive Steroids with Structural Diversity from the South China Sea Soft Coral sp. and Sponge sp.
Mar Drugs
January 2025
Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China.
A chemical investigation of the soft coral sp. and the sponge sp. from the South China Sea led to the isolation of five steroids, including two new compounds ( and ) and one known natural product ().
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!