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Alkaloid Songorine Exerts Potent Gamma-Aminobutyric Acid-A Receptor Agonist Action In Vivo and Effectively Decreases Anxiety without Adverse Sedative or Psychomotor Effects in the Rat.
Pharmaceutics
September 2022
Grastyán Endre Translational Research Centre, University of Pécs, 6 Ifjúság Str., H-7624 Pécs, Hungary.
Songorine (SON) is a diterpenoid alkaloid from plants. Preparations of Aconitum roots have been employed in traditional oriental herbal medicine, however, their mechanisms of action are still unclear. Since GABA-receptors are possible brain targets of SON, we investigated which subtypes of GABA-receptors contribute to the effects of SON, and how SON affects anxiety-like trait behavior and psychomotor cognitive performance of rats.
View Article and Find Full Text PDFDopamine modulates subcortical responses to surprising sounds.
PLoS Biol
June 2020
Cognitive and Auditory Neuroscience Laboratory (CANELAB), Institute of Neuroscience of Castilla y León (INCYL), Salamanca, Spain.
Dopamine guides behavior and learning through pleasure, according to classic understanding. Dopaminergic neurons are traditionally thought to signal positive or negative prediction errors (PEs) when reward expectations are, respectively, exceeded or not matched. These signed PEs are quite different from the unsigned PEs, which report surprise during sensory processing.
View Article and Find Full Text PDFN-Methyl-d-aspartate receptor open-channel blockers memantine and magnesium modulate nociceptive trigeminovascular neurotransmission in rats.
Eur J Neurosci
September 2019
Department of Neurology, University of California, San Francisco, California, USA.
Experimental and clinical studies suggest that the low-affinity N-methyl-d-aspartate (NMDA) receptor open-channel blockers Mg and memantine are effective in reducing trigeminal nociceptive activation. The aim of this study was to investigate the apparent effectiveness of these channel blockers using a model of trigeminal activation in vivo. Rats were anaesthetized before electrically stimulating the dura mater adjacent the middle meningeal artery.
View Article and Find Full Text PDFBrain Distribution and Modulation of Neuronal Excitability by Indicaxanthin From Administered at Nutritionally-Relevant Amounts.
Front Aging Neurosci
May 2018
Department of Experimental Biomedicine and Clinical Neuroscience (Bio.Ne.C.), Sezione di Fisiologia Umana G. Pagano, University of Palermo, Palermo, Italy.
Several studies have recently investigated the role of nutraceuticals in complex pathophysiological processes such as oxidative damages, inflammatory conditions and excitotoxicity. In this regard, the effects of nutraceuticals on basic functions of neuronal cells, such as excitability, are still poorly investigated. For this reason, the possible modulation of neuronal excitability by phytochemicals (PhC) could represent an interesting field of research given that excitotoxicity phenomena are involved in neurodegenerative alterations leading, for example, to Alzheimer's disease.
View Article and Find Full Text PDFLongitudinal observations using simultaneous fMRI, multiple channel electrophysiology recording, and chemical microiontophoresis in the rat brain.
J Neurosci Methods
August 2018
Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA. Electronic address:
Background: fMRI blood oxygenation level-dependent (BOLD) signal has been widely used as a surrogate for neural activity. However, interpreting differences in BOLD fMRI based on underlying neuronal activity remains a challenge. Concurrent rsMRI data collection and electrophysiological recording in combination with microiontophoretically injected modulatory chemicals allows for improved understanding of the relationship between resting state BOLD and neuronal activity.
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