AI Article Synopsis
- Two new beta blockers were tested for their impact on renal function, showing significant reductions in urine flow and the excretion of urea, sodium, and chloride right after acute use.
- While fractional excretion of sodium (FeNa) decreased initially, it stabilized during long-term use.
- After two months of treatment, both blood pressure and plasma renin activity were significantly lower, indicating a potential increase in the need for diuretics in patients with unstable cardiovascular conditions.
Article Abstract
The effects of two new beta blockers on renal function have been studied. There were significant decreases in urine flow, urea clearance, sodium and chloride excretion rates after acute administration. Fractional excretion of sodium (FeNa) fell significantly but did not continue to fall during chronic administration. Blood pressure and plasma renin activity decreased significantly after two months' therapy. These findings suggest that beta blockers in patients with unstable cardiovascular function increase the need for concomitant diuretic therapy.
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