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Single-Cell Multi-Omics Profiling of Immune Cells Isolated from Atherosclerotic Plaques in Male ApoE Knockout Mice Exposed to Arsenic.
Environ Health Perspect
January 2025
Division of Experimental Medicine, Department of Medicine, McGill University, Montréal, Canada.
Background: Millions worldwide are exposed to elevated levels of arsenic that significantly increase their risk of developing atherosclerosis, a pathology primarily driven by immune cells. While the impact of arsenic on immune cell populations in atherosclerotic plaques has been broadly characterized, cellular heterogeneity is a substantial barrier to in-depth examinations of the cellular dynamics for varying immune cell populations.
Objectives: This study aimed to conduct single-cell multi-omics profiling of atherosclerotic plaques in apolipoprotein E knockout () mice to elucidate transcriptomic and epigenetic changes in immune cells induced by arsenic exposure.
Real-Life Experience with Tildrakizumab in Plaque Psoriasis with Palmoplantar Involvement: A Multi-Center Retrospective Italian Study.
Dermatol Ther (Heidelb)
January 2025
Department of Clinical and Molecular Sciences-Dermatological Clinic, Università Politecnica Delle Marche, Ancona, Italy.
Introduction: Palmoplantar psoriasis (PPp) has a profound negative impact on patients' quality of life, and it represents a therapeutic challenge, as palms and soles are difficult to treat area. Although the efficacy profile of tildrakizumab has been well evaluated in the literature, data on its use for PPp are still limited. The objective of the study was to evaluate the efficacy and safety of tildrakizumab on moderate-to-severe plaque psoriasis with involvement of the palmoplantar area.
View Article and Find Full Text PDFSuprasternal aortic arch echocardioscopy as a potential tool in detection and follow-up of mobile thrombi in patients with ischemic stroke.
Front Neurol
January 2025
Neurology Department, Navarre University Hospital, Pamplona, Navarra, Spain.
Introduction: Severe or complicated atheromatosis of the aortic arch represents an important and often underdiagnosed embolic source in patients with ischemic stroke. The presence of a floating thrombus has significant clinical relevance, as it is associated with a high risk of early recurrence. The aim of this study was to analyze the potential of echocardiographic examination through the suprasternal window in both the detection of embolic sources and the monitoring of the response to anticoagulant treatment in patients with mobile thrombi.
View Article and Find Full Text PDFTreatment with Autologous Adipose-derived Regenerative Cells for Peyronie's Disease in Men: The Straight @head Pilot Study.
Eur Urol Open Sci
January 2025
Clinical Institute, University of Southern Denmark, Odense, Denmark.
Background And Objective: We evaluated the effectiveness of injecting autologous adipose-derived regenerative cells (ADRCs) into plaque in men with chronic Peyronie's disease (PD).
Methods: This pilot safety study recruited 22 Danish men with chronic PD from an outpatient clinic. Patients received one bolus of ADRCs injected into plaque, with follow-ups at 1, 3, 6, and 12 mo.
Investigation of the Effect of Periodontitis on Trabecular Bone Structure by Fractal Analysis.
Cureus
January 2025
Oral and Maxillofacial Radiology, Biruni University, İstanbul, TUR.
Objective: This study aimed to evaluate the trabecular microarchitecture in the interdental region of panoramic radiographs from periodontally healthy individuals and those with stage III/IV periodontitis using fractal analysis (FA), while also assessing the relationship between clinical periodontal parameters and FA outcomes.
Study Design: Clinical and radiographic records of 20 periodontally healthy individuals and 19 individuals with stage III/IV periodontitis were included. Clinical measurements including the plaque score, bleeding on probing, probing pocket depth, and clinical attachment level were recorded.
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