In the present study the interaction of aminoglycoside antibiotics with oxytocin and prostaglandin E2 on the contractility of the rat uterus was investigated. It was found that oxytocin and prostaglandin E2 were able to completely reverse the uterine relaxing effect of aminoglycoside antibiotics and when administered concomitantly they exert a protective action. These findings support the view that aminoglycoside antibiotics affect superficially bound extracellular calcium only, since oxytocin and prostaglandins primarily act on intracellular calcium.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
aminoglycoside antibiotics
16
oxytocin prostaglandin
12
interaction aminoglycoside
8
antibiotics oxytocin
8
antibiotics
4
oxytocin
4
prostaglandin uterine
4
uterine contractility
4
contractility study
4
study interaction
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!