Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/bi00257a012 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
An efficient, amine-specific iTRAQ labeling method improves the peptide and protein identification rates.
J Proteomics
August 2024
Shanghai Institute of Precision Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China. Electronic address:
Isotope tags for relative and absolute quantification (iTRAQ) are among the most widely used proteomics quantification techniques. These tags can be rapidly coupled to the primary amines of proteins/peptides through chemical reactions under mild conditions, making this technique universally applicable to any kind of sample. However, iTRAQ reagents also partially react with the hydroxyl groups of serine, threonine and tyrosine residues, particularly when these residues coexist with a histidine residue in the same peptide.
View Article and Find Full Text PDFUnprecedented complexity of six coexisting autoimmune diseases: A case report.
Tunis Med
February 2024
Internal medicine department, Sahloul university hospital, Sousse, Tunisia. Faculty of medicine, University of Sousse, Tunisia.
Introduction: Autoimmune disorders often exhibit interconnectedness, although encountering multiple autoimmune conditions in a single patient is uncommon. Multiple autoimmune syndrome is characterized by the presence of at least three distinct autoimmune diseases in an individual. This report outlines the case of a middle-aged woman diagnosed with autoimmune thyroiditis, Sjögren's syndrome, scleroderma, autoimmune hepatitis, primary biliary cirrhosis, and antisynthetase syndrome.
View Article and Find Full Text PDFThe tsRNAs (tRFdb-3013a/b) serve as novel biomarkers for colon adenocarcinomas.
Aging (Albany NY)
March 2024
Chongqing Medical University, Chongqing 400016, China.
The tsRNAs (tRNA-derived small RNAs) are a novel class of small non-coding RNAs derived from transfer-RNAs. Colon adenocarcinoma (COAD) is the most malignant intestinal tumor. This study focused on the identification and characterization of tsRNA biomarkers in colon adenocarcinomas.
View Article and Find Full Text PDFTMT Labeling under Acidic pH Overcomes Detrimental Overlabeling and Improves Peptide Identification Rates.
Anal Chem
July 2023
Shanghai Institute of Precision Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China.
Tandem mass tags (TMT) are one of the most widely used techniques in proteomics quantification due to their ability to accurately and precisely analyze up to 18 samples in a multiplexed manner. Moreover, TMT tags are introduced chemically by covalent coupling of the primary amines of digested proteins, making them universally applicable for any kind of sample. However, in addition to amine groups, the hydroxyl groups of serine, threonine, and tyrosine residues can also be labeled to some extent during TMT labeling, which compromises the analytical sensitivity and results in lower peptide identification rates compared to label-free methods.
View Article and Find Full Text PDFDesign and Synthesis of Oligopeptidic Parvulin Inhibitors.
ChemMedChem
June 2022
Institute of Biostructures and Bioimaging, National Research Council, 80131, Naples, Italy.
Pin1 catalyzes the cis-trans isomerization of pThr-Pro or pSer-Pro amide bonds of various proteins involved in several physio/pathological processes. In this framework, recent research activity is directed toward the identification of new selective Pin1 inhibitors. Here, we developed a set of peptide-based Pin1 inhibitors.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!