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Bispidine Chelators for Radiopharmaceutical Applications with Lanthanide, Actinide, and Main Group Metal Ions.
Inorg Chem
December 2023
Universität Heidelberg, Anorganisch-Chemisches Institut, INF 270, 69120 Heidelberg, Germany.
Octadentate and specifically nonadentate ligands with a bispidine scaffold (3,7-diazabicyclo[3.3.1]nonane) are known to be efficiently coordinated to a range of metal ions of interest in radiopharmaceutical chemistry and lead to exceedingly stable and inert complexes.
View Article and Find Full Text PDFA preliminary study of imaging paclitaxel-induced tumor apoptosis with (99)Tc(m)-His10-Annexin V.
Chin Med J (Engl)
March 2014
Department of Nuclear Medicine, China-Japan Friendship Hospital, Beijing 100029, China.
Background: In tumors the process of apoptosis occurs over an interval of time after chemotherapy. It is important to determine the best time for detecting apoptosis by in vivo imaging. In this study, we evaluated the dynamics and feasibility of imaging non-small cell lung cancer (NSCLC) apoptosis induced by paclitaxel treatment using a (99)Tc(m)-labeled Annexin V recombinant with ten consecutive histidines (His10-Annexin V) in a mouse model.
View Article and Find Full Text PDFRadiotolerance of phosphatases of a Serratia sp.: potential for the use of this organism in the biomineralization of wastes containing radionuclides.
Biotechnol Bioeng
August 2012
School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Aqueous wastes from nuclear fuel reprocessing present special problems of radiotoxicity of the active species. Cells of Serratia sp. were found previously to accumulate high levels of hydrogen uranyl phosphate (HUP) via the activity of a phosphatase enzyme.
View Article and Find Full Text PDFThe dynamics of transition process caused by gamma-irradiation in bacterial Escherichia coli JM 101 culture was investigated. The bacteria radiostability at different phases of this process was defined. The received results testified to phase gamma-irradiation doze dependent character of bacteria population reaction.
View Article and Find Full Text PDF[Effect of nitric oxide donor (NaNO2) on the stability of non-transformed and malignant cells to ultraviolet and gamma-radiation].
Tsitologiia
August 2004
St. Petersburg Nuclear Physics Institute RAS, Gatchina, Leningrad District.
A decreased sensitivity of the Chinese hamster cells (line V-79) to gamma-radiation under the influence of nitric oxide induction was shown elsewhere. This effect is connected hypothetically with post-radiation reparation of DNA. The investigation of the nitric oxide donor effect on sensitivity of these to UV-radiation is of interest, because this radiation is an important ecological factor of the environment.
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