An elevation of erythrocyte (RBC) glycine was observed in a group of patients with bipolar affective disorder who were being treated with lithium (Li) carbonate. A maximal increase of 90% or more was generally attained after about 100 days of Li intake and was maintained for 2 years or longer. After 3 or more years of Li therapy, the RBC glycine had often returned to the normal range. Abrupt withdrawal of Li in such a case produced an immediate, dramatic, and paradoxical increase in RBC glycine which lasted for 100 days. Plasma glycine was not affected by Li.
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