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Isatidis root polysaccharides ameliorates post-weaning diarrhea by promoting intestinal health and modulating the gut microbiota in piglets.
Vet Q
December 2025
Animal Nutritional Genome and Germplasm Innovation Research Center, College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.
This study aimed to investigate the effects of dietary isatidis root polysaccharide (IRP) on diarrhea, immunity, and intestinal health in weanling piglets. Forty healthy piglets were randomly assigned to five groups receiving varying dosages of IRP. The findings indicated that different concentrations of IRP significantly reduced diarrhea scores ( < 0.
View Article and Find Full Text PDFTrichinella spiralis excretory/secretory antigens ameliorate porcine epidemic diarrhea virus-induced mucosal damage in porcine intestinal oganoids by alleviating inflammation and promoting tight junction.
Int J Parasitol
December 2024
State Key Laboratory for Animal Disease Control and Prevention, Key Laboratory of Veterinary Parasitology of Gansu Province, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Disease, Yangzhou 225009, China. Electronic address:
Article Synopsis
- This study examines the interactions between the swine pathogens Trichinella spiralis and porcine epidemic diarrhea virus (PEDV) using porcine intestinal organoids as a model.
- Results show that T. spiralis excretory/secretory antigens (TsES) can inhibit pro-inflammatory responses and aid in mucosal repair in PEDV-infected organoids.
- The findings suggest that TsES not only help manage inflammation and tissue damage but may also enhance PEDV replication, highlighting their potential role in therapeutic strategies for intestinal inflammation.
Inhibition of CFTR-mediated intestinal chloride secretion by nornidulin: Cellular mechanisms and anti-secretory efficacy in human intestinal epithelial cells and human colonoids.
PLoS One
December 2024
Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bang Phli, Samut Prakarn, Thailand.
Secretory diarrhea, a major global health concern, particularly among young children, is often characterized by excessive chloride secretion through the cystic fibrosis transmembrane conductance regulator (CFTR) channel. Nornidulin, a fungus-derived natural product from Aspergillus unguis, has previously been shown to inhibit cAMP-induced Cl- secretion in T84 cells (human intestinal cell lines). However, the cellular mechanism of nornidulin in inhibiting cAMP-induced Cl- secretion and its anti-secretory efficacy is still unknown especially in a human colonoid model, a preclinical model recapitulating intestinal physiology in humans.
View Article and Find Full Text PDFCo-frequency or contrary? The effects of Qiwei Baizhu Powder and its bioactive compounds on mucosa-associated microbiota of mice with antibiotic-associated diarrhea.
Front Cell Infect Microbiol
November 2024
School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China.
Article Synopsis
- Qiwei Baizhu Powder (QWBZP) is effective in treating antibiotic-associated diarrhea (AAD) by regulating gut microbiota, but the specific role of its bioactive compounds remains unclear.
- In a study with 24 mice, different groups received either QWBZP decoction, QWBZP-TG, or sterile water to assess changes in gut microbiota and various immune markers after inducing AAD.
- Results indicated that QWBZP-TG notably improved microbiota diversity and reduced inflammatory markers more effectively than QWBZP decoction, suggesting glycosides in QWBZP help alleviate diarrhea symptoms by inhibiting harmful bacteria and modulating the immune response.
When and What to Test for Diarrhea: Focus on Stool Testing.
Am J Gastroenterol
October 2024
Division of Gastroenterology and Hepatology, Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Mayo Clinic, Rochester, Minnesota, USA .
Introduction: To review stool diagnostic tests in acute and chronic diarrhea.
Methods: Narrative review of published literature.
Results: In acute diarrhea, stool tests are indicated when there is strong pretest probability of infectious etiology or Clostridioides difficile infection suggested by > 3 unformed bowel movements per 24 hours, symptoms lasting >7 days, and circumstances that are suggestive of infection.
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