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Randomized, Placebo-Controlled, Phase 1 Safety Study of Oral Mucosal Immunotherapy in Peanut Allergic Adults.
Ann Allergy Asthma Immunol
January 2025
Intrommune Therapeutics, Inc., New York.
Background: Oral Mucosal Immunotherapy (OMIT) uses a specifically formulated toothpaste to deliver allergenic proteins to immunologically active areas of the oral cavity. This represents a new delivery mechanism with several features designed to improve food allergy desensitization. OMIT presents advantages over other approaches to allergy immunotherapy due to its targeted delivery and simplified administration.
View Article and Find Full Text PDFResin composite aggregated S-PRG particles are not superior to non-S-PRG under microcosm biofilm.
Sci Rep
January 2025
Institute of Biology (Inbio), Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.
This study assessed the effect of composite resins, aggregated or not with S-PRG particles, and the use of toothpaste in controlling demineralization and bacterial growth. Human molars were distributed into 3 groups: control (CT) - sound teeth, Beautifil Bulk Restorative System (aggregated with S-PRG) (BB), Filtek One Bulk Fill (without S-PRG) (FB). Teeth destined for groups BB and FB previously received Class I preparations (4 × 4 × 4 mm), followed by single-increment restorations.
View Article and Find Full Text PDFComparative Evaluation of Two Novel Natural Desensitizing Agents on Dentinal Tubule Occlusion: A Scanning Electron Microscopy Study.
J Contemp Dent Pract
September 2024
Department of Conservative Dentistry and Endodontics, PMNM Dental College and Hospital, Bagalkot, Karnataka, India.
Aim: The present study is aimed to compare the effectiveness of dentinal tubule occlusion of two natural-based desensitizing toothpaste (Bentodent Desensitizer and Fang Farm Mint) and Novamin-based toothpaste (Shy-NM) under scanning electron microscope (SEM).
Materials And Methods: A total of 60 root dentin discs (3 mm-thick) were obtained from recently extracted permanent premolar teeth and were randomly divided into four groups based on the desensitizing toothpaste used, each group with 15 samples: Group I: Control, group II: Shy-NM, group III: Bentodent desensitizer, group IV: Fang Farm Mint. Samples were brushed for 2 min twice daily with a soft toothbrush with respective pea size amount of toothpaste for 14 days manually.
Effect of different protocols in preventing demineralization in irradiated human enamel, in vitro study.
BMC Oral Health
January 2025
Department of Operative Dentistry, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
Background: This in vitro study evaluated the efficacy of professional and home-use fluoride regimens for protecting irradiated enamel, undergoing pH cycling resembling xerostomia.
Methods: Sixty human premolar teeth were irradiated with a total dose of 70 Gy and subsequently sectioned into 3 × 3 cm enamel slabs. These slabs were randomly distributed into five groups (n = 12 per group): professional-use groups received fluoride varnish either weekly (FV1) or biweekly (FV2); home-use groups applied 5000 ppm (FT5) or 1450 ppm (FT) fluoride toothpaste; and a control group (control) received no treatment.
Biomimetic and protective effects of bioactive toothpastes on eroded enamel surfaces.
Braz Oral Res
January 2025
Universidade Federal da Paraíba - UFPB, Health Science Center Department of Clinical and Community Dentistry, João Pessoa, PB, Brazil.
This study aimed to evaluate the effectiveness of bioactive toothpastes in remineralizing eroded enamel surfaces in vitro. Bovine enamel blocks (n = 48) were obtained and classified into untreated, demineralized, and treated areas. Specimens were randomly classified into six groups (n = 8 each): fluoride-free toothpaste (NCT), Colgate Total 12 (PCT), Sensodyne Repair and Protect (SRP), Sensodyne Pronamel (SPE), Regenerador + Sensitive (RGS), and RGS/calcium booster (RCB).
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