Individual Hereford cows with naturally occurring ocular squamous cell carcinoma were treated by intralesional injections of mycobacterial cell walls in an oil-in-water emulsion. Six of 23 treated animals were alive (5 free of tumor and 1 with arrested disease) at a minimum of 2.5 years after treatment, as compared to 1 of 18 controls. A necropsy, lymph node metastases were found in most animals with progressive disease. The disease progressed to an advanced stage (which required death of the animals) at a faster rate for control animals than for treated animals.
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