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Myelin oligodendrocyte glycoprotein antibody-associated disease: an immunopathological study.
Brain
May 2020
Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Article Synopsis
- MOG antibodies are found in patients with conditions like optic neuritis and encephalitis, but rarely in classic multiple sclerosis.
- There hasn’t been a thorough investigation into how MOG antibodies relate to demyelinating lesions and the immune response.
- In analyzing brain tissue from 11 patients, most lesions displayed a specific demyelination pattern resembling ADEM, with distinct characteristics different from other demyelinating diseases.
[DPB 1 *0501-associated opticomyelitis and atopic myelitis: novel disease entities].
Rinsho Shinkeigaku
January 1999
Department of Neurology, Neurological Institute, Faculty of Medicine, Kyushu University.
To clarify the relationship between Th 1/Th 2 balance and clinical features, we studied the intracellular IFN gamma-positive versus IL-4-positive cell ratio in peripheral blood CD 4 T cells by flow cytometry and measured total and allergen-specific IgE by ELISA in 227 patients with various neurologic diseases including multiple sclerosis (MS), myelitis and HAM/TSP, and 42 healthy hospital subjects. The intracellular IFN gamma/IL-4 ratio in the patients with acute myelitis was significantly decreased, and the total serum IgE level and frequency of mite antigen-specific IgE were significantly elevated as compared with the controls. Patients with HAM/TSP, however, had a significantly higher intracellular IFN gamma/IL-4 ratio, lower total IgE level, and lower frequency of cedar pollen-specific IgE than did the controls.
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