AI Article Synopsis
- Injection of 25 micrograms of methoxytryptamine (5-MT) in adult male hamsters led to testicular involution when administered in the late afternoon over 51 days.
- Administering 5-MT in the morning did not result in any regression of the testes.
- Unlike 5-MT, the compound 5-methoxytryptophan (5-MTP) did not cause gonadal atrophy regardless of the time of day, suggesting a role for 5-MT in reproductive function similar to that of melatonin.
Article Abstract
S.c. injection of 25 microgram of methoxytryptamine (5-MT) in oil into adult male hamsters given between 4.30 and 5 p.m. (light on from 5 a.m. to 7 p.m.: 14 L/10 D) for 51 consecutive days caused involution of the testes. Similar injections of 5-MT given between 8.30 and 9.30 a.m. completely failed to cause regression of the gonads. Under the same conditions, 5-methoxytryptophan (5-MTP) did not induce gonadal atrophy, neither in the morning nor in the late afternoon. These results indicate that, like malatonin, 5-methoxytryptamine is implicated in the control of the reproductive function.
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| http://dx.doi.org/10.1007/BF01248961 | DOI Listing |
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