Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Localized In Vivo Prodrug Activation Using Radionuclides.
J Nucl Med
January 2025
Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts;
Radionuclides used for imaging and therapy can show high molecular specificity in the body with appropriate targeting ligands. We hypothesized that local energy delivered by molecularly targeted radionuclides could chemically activate prodrugs at disease sites while avoiding activation in off-target sites of toxicity. As proof of principle, we tested whether this strategy of radionuclide-induced drug engagement for release (RAiDER) could locally deliver combined radiation and chemotherapy to maximize tumor cytotoxicity while minimizing off-target exposure to activated chemotherapy.
View Article and Find Full Text PDFLaparoscopic Anatomical Liver Resection for the Patients With Constitutional Indocyanine Green Excretory Defect: A Case Report.
Asian J Endosc Surg
January 2025
Department of Gastroenterological Surgery, Miyagi Cancer Center, Natori, Japan.
Constitutional indocyanine green (ICG) excretion defect (CIED) is a rare clinical condition characterized by markedly delayed ICG disappearance with other normal liver function tests. Here, we report a case of CIED in which laparoscopic anatomical liver resection was successfully performed using ICG fluorescence staining. A 64-year-old man with a 4-cm tumor located in the liver segment 5 was referred to our hospital.
View Article and Find Full Text PDFConsiderations and Indications for Gastric Emptying Scintigraphy in Lung Transplant Patients.
Asia Ocean J Nucl Med Biol
January 2025
Temple University Hospital Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Philadelphia, PA USA.
Objectives: Gastroparesis is a complication following lung transplantation. This study aimed to assess the prevalence of gastroparesis in patients with lung transplants undergoing solid phase gastric emptying scintigraphy (GES). Specifically, we investigated which type of lung transplant is more susceptible to gastroparesis and whether timing of GES post-transplantation impacts diagnosis of severe gastroparesis.
View Article and Find Full Text PDFComparison Between Prone SPECT-Based Semi-Quantitative Parameters and MBI-Based Semi-Quantitative Parameters in Patients with Locally Advanced Breast Cancer.
Mol Imaging Biol
December 2024
Department of Nuclear Medicine, Alrijne Hospital, Leiderdorp, The Netherlands.
Article Synopsis
- This study assesses the effectiveness of prone SPECT imaging with [Tc]Tc-sestamibi compared to Molecular Breast Imaging (MBI) in predicting treatment response in women with locally advanced breast cancer (LABC).
- It involved 18 patients who underwent SPECT scans shortly after and 90 minutes post-injection, along with MBI, to analyze tumor characteristics like wash-out rates and standardized uptake values.
- Results indicated that early SPECT provided useful semi-quantitative data comparable to MBI, though further research with broader clinical parameters is necessary to determine the clinical implications of these findings.
Assessment of post-pyeloplasty renal drainage in antenatally detected hydronephrosis by Tc-L, L-Ethylenedicysteine renal scintigraphy: the importance of delayed imaging.
Ann Nucl Med
November 2024
Department of Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Objective: Diuretic renal scintigraphy is important in diagnosing pelvi-ureteric junction obstruction (PUJO) in antenatally detected hydronephrotic (ANH) kidneys. Early-phase dynamic renal scintigraphy has several pitfalls contributing to the false interpretation of obstructed drainage, especially after pyeloplasty. This study explores the utility of delayed imaging in Tc-L,L-Ethylenedicysteine (EC) diuretic renal scintigraphy to assess post-pyeloplasty renal drainage in ANH.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!