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The Expression of HIF-1α and VEGF in Radicular Cysts and Periapical Granulomas.
Eur J Dent
December 2024
College of Medicine, Research and Graduate Studies, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.
Objectives: This study aimed to evaluate the expression levels of hypoxia-inducible factor 1-α (HIF-1α) and vascular endothelial growth factor (VEGF) in radicular cysts and periapical granulomas, thereby contributing to the understanding of their potential significance in the differential diagnosis and treatment of these lesions.
Materials And Methods: In the present cross-sectional study, 51 samples of periapical lesions were included. Of them, 24 samples were radicular cysts, and 27 samples were periapical granulomas.
CD34 and Ki-67 Immunoexpression in Periapical Granulomas: Implications for Angiogenesis and Cellular Proliferation.
Diagnostics (Basel)
October 2024
Department of Microscopic Morphology/Histology, Angiogenesis Research Center, "Victor Babeș" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Background/objectives: The main mechanism of the formation of granulation tissue is the progression of an infection from the tooth to the periapical bone. At this level, the immune system tries to localize and annihilate the microorganism's injury. Ki-67 is a protein directly associated with the cell proliferation rate, while CD34 is a biomarker involved in angiogenesis, and studies suggest that they both have a positive correlation with the intensity of the local inflammatory infiltrate.
View Article and Find Full Text PDFA rare case report on endodontic management of calcified structures within large periapical pathology: An 8-year follow-up outcome.
J Conserv Dent Endod
September 2024
Department of Dentistry, All India Institute of Medical Sciences, Rajkot, Gujarat, India.
Periapical lesions with mixed radiographic appearance can have odontogenic or nonodontogenic origin. A number of neoplastic lesions either benign or malignant can present as radiolucent, radiopaque, or mixed in jaws and if present near the root apices can be misdiagnosed as odontogenic infection/etiology. The present case report describes a rare case of two elongated radiopaque structures within periapical pathology located beneath the apices of mandibular central incisors in a 26-year-old male.
View Article and Find Full Text PDFReactivation of Epstein-Barr virus by n-butyric acid from Pseudoramibacter alactolyticus induces inflammatory cytokines in periapical granulomas.
J Oral Biosci
October 2024
Department of Endodontics, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-0062, Japan; Division of Advanced Dental Treatment, Dental Research Center, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-0062, Japan. Electronic address:
Objectives: This study investigates whether latent Epstein-Barr virus (EBV) can be reactivated by n-butyric acid from Pseudoramibacter alactolyticus, and if such reactivation induces expression of interleukin (IL)-1β and IL-6 in periapical granulomas.
Methods: We analyzed periapical granulomas and healthy gingival tissues to detect the presence of EBV and P. alactolyticus.
Prevalence of Incidental Findings and Assessment of Maxillary Sinus Pathologies and Dental Diseases Using Cone-Beam Computed Tomography (CBCT) in the Tamil Nadu Population: A Retrospective Study.
Cureus
September 2024
Department of Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Article Synopsis
- Cone-beam computed tomography (CBCT) is a useful imaging method for diagnosing dental issues and understanding the link between maxillary sinuses and dental roots, emphasizing the need for careful assessment of incidental findings.
- A study analyzed CBCT scans from 300 individuals between 18 to 70 years old to evaluate the prevalence of incidental maxillary sinus pathologies and their connection to dental diseases.
- Findings revealed that 52.05% of subjects had incidental maxillary sinus findings, with a higher occurrence in males and those aged 46 to 55, showing various associations between sinus issues and dental conditions.
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