One hundred and ninety-six albino male rats [Crl/COBS CD (SD) BR] were given 1,000 ppm trisodium nitrilotriacetic acid (NTA) in drinking water for 2 years. One hundred and ninety-two control rats were given water without NTA. Animals that had a palpable mass or that appeared clinically ill were killed. All survivors were killed at 704 days. A significantly (P less than 0.05) higher proportion of the NTA-treated rats vs. 11.2% of the controls). The largest difference between the NTA-treated rats and the controls in tumor incidence was associated with renal adenoma. The NTA-treated group contained 25 rats with renal adenomas and 4 with renal adenocarcinomas. Only 5 control rats had renal adenomas; none had renal adenocarcinomas. No statistically significant differences were observed for any of the other tumor types among the NTA-treated rats and the controls. The overall incidence of renal tubular cell hyperplasia and nephritis was similar in the treated and control groups. However, a significantly greater number of NTA-treated rats had more severe grades of hyperplasia. Thus NTA when administered continuously in drinking water at a concentration of 1,000 ppm is tumorigenic to the rat kidney.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Background: The most abundant plant sterol β-sitosterol is widely used for treating heart diseases and chronic inflammatory conditions. The objective of the current study was to evaluate the nephroprotective effect of β-sitosterol against nephrotoxicants which were studied using renal function markers, antioxidant and lipid peroxidation status, and inflammatory markers.
Methods: Male albino Wistar rats were randomly grouped into four: group 1 was vehicle control rats (0.
Ameliorative effect of butylated hydroxyanisole against ferric nitrilotriacetate-induced hepatotoxicity and oxidative stress in rats.
Toxicol Ind Health
November 2015
Biotechnology Research Institute, Universiti Malaysia Sabah, Kota Kinabalu Sabah, Malaysia.
Ferric nitrilotriacetate (Fe-NTA) is a known renal carcinogen and has been shown to adversely induce oxidative stress and tissue toxicity after both acute and chronic exposure. Present studies were designed to study the hepatoprotective and antioxidant potential of butylated hydroxyanisole (BHA), a phenolic antioxidant used in foods on ferric nitrilotriacetate (Fe-NTA) induced hepatotoxicity in rats. Male albino rats of Wistar strain (4-6 weeks old) weighing 125-150 g were used in this study.
View Article and Find Full Text PDFAntioxidant and nephroprotective potential of butylated hydroxyanisole against ferric nitrilotriacetate-induced oxidative stress and early tumor events.
Hum Exp Toxicol
April 2016
Biotechnology Research Institute, Universiti Malaysia Sabah, Jalan UMS, Kota KinabaluSabah, Malaysia.
The present study was aimed to study protective effect of butylated hydroxyanisole (BHA), a phenolic antioxidant used in foods on ferric nitrilotriacetate (Fe-NTA)-induced nephrotoxicity. Male albino rats of Wistar strain (4-6 weeks old) weighing 125-150 g were used in this study. Animals were given a single dose of Fe-NTA (9 mg kg(-1) body weight) after treatment with BHA (1 and 2 mg animal(-1) day(-1)).
View Article and Find Full Text PDFProtective effect of ethanolic extract of Tabernaemontana divaricata (L.) R. Br. against DEN and Fe NTA induced liver necrosis in Wistar Albino rats.
Biomed Res Int
May 2015
Department of Biochemistry, Karpagam University, Coimbatore, Tamil Nadu 641021, India ; Department of Bioinformatics, Karpagam University, Coimbatore, Tamil Nadu 641021, India.
This study is an attempt to evaluate the hepatoprotective activity of Tabernaemontana divaricata against DEN and Fe NTA induced liver necrosis in rats. Ethanolic extract of the whole plant of Tabernaemontana divaricata at doses of 200 and 400 mg/kg body weight and 5-fluorouracil (standard drug) was orally administered to male Wistar Albino rats once daily for 24 weeks, simultaneously treated with the carcinogen DEN and Fe NTA. In simultaneously treated animals, the plant extract significantly decreased the levels of uric acid, bilirubin, AST, ALT, and ALP in serum and increased the levels of liver marker enzymes in liver.
View Article and Find Full Text PDFConsumption of hydrogen-rich water protects against ferric nitrilotriacetate-induced nephrotoxicity and early tumor promotional events in rats.
Food Chem Toxicol
November 2013
Department of Urology, Zhejiang Cancer Hospital, Hang Zhou 310022, Zhejiang Province, China.
The aim of this work was to test whether consumption with hydrogen-rich water (HW) alleviated renal injury and inhibited early tumor promotional events in Ferric nitrilotriacetate (Fe-NTA)-treated rats. Rats were injected with Fe-NTA solution (7.5mg Fe/kg body weight) intraperitoneally to induce renal injury and simultaneously treated with HW (1.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!