Sixty-nine rat mandibular molars were exposed surgically, and the pulpal response to ZOE with a purified form of eugenol versus ZOE with stock eugenol was investigated. Evaluation and analysis of the control and experimental specimens at 1, 3, 7 and 21 days indicated that there were no differences in the amount of inflammation observed between the two groups. Thus, it may be inferred from the results of this study that the impurities found in stock eugenol are not of clinical significance.
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