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Metabolic Reprogramming of Neural Stem Cells by Chiral Nanofiber for Spinal Cord Injury.
ACS Nano
January 2025
Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Exogenous neural stem cells (NSCs) have great potential to reconstitute damage spinal neural circuitry. However, regulating the metabolic reprogramming of NSCs for reliable nerve regeneration has been challenging. This report discusses the biomimetic dextral hydrogel (DH) with right-handed nanofibers that specifically reprograms the lipid metabolism of NSCs, promoting their neural differentiation and rapid regeneration of damaged axons.
View Article and Find Full Text PDFA Highly Bioactive Organic-Inorganic Nanoparticle for Activating Wnt10b Mediated Osteogenesis by Specifically Anchor CCN3 Protein.
Adv Healthc Mater
January 2025
Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, P. R. China.
The rapid and efficient bone regeneration is still in unsatisfactory outcomes, demonstrating alternative strategy and molecular mechanism is necessary. Nanoscale biomaterials have shown some promising results in enhancing bone regeneration, however, the detailed interaction mechanism between nanomaterial and cells/tissue formation is not clear. Herein, a molecular-based inorganic-organic nanomaterial poly(citrate-siloxane) (PCS) is reported which can rapidly enhance osteogenic differentiation and bone formation through a special interaction with the cellular surface communication network factor 3 (CCN3), further activating the Wnt10b/β-catenin signaling pathway.
View Article and Find Full Text PDFEndothelial cells under disturbed flow release extracellular vesicles to promote inflammatory polarization of macrophages and accelerate atherosclerosis.
BMC Biol
January 2025
Institute of Biomedical Engineering, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, 610041, China.
Background: Extracellular vesicles (EVs) derived from endothelial cells (ECs) are increasingly recognized for their role in the initiation and progression of atherosclerosis. ECs experience varying degrees and types of blood flow depending on their specific arterial locations. In regions of disturbed flow, which are predominant sites for atherosclerotic plaque formation, the impact of disturbed flow on the secretion and function of ECs-derived EVs remains unclear.
View Article and Find Full Text PDFPalatal segment contributions to midfacial anterior-posterior growth.
J Anat
January 2025
Department of Anthropology, Stony Brook University, Stony Brook, New York, USA.
Anterior-posterior (A-P) elongation of the palate is a critical aspect of integrated midfacial morphogenesis. Reciprocal epithelial-mesenchymal interactions drive secondary palate elongation that is coupled to the periodic formation of signaling centers within the rugae growth zone (RGZ). However, the relationship between RGZ-driven morphogenetic processes, the differentiative dynamics of underlying palatal bone mesenchymal precursors, and the segmental organization of the upper jaw has remained enigmatic.
View Article and Find Full Text PDFCephalometric analysis of Indian races: A systematic review.
Natl J Maxillofac Surg
November 2024
Department Oral and Maxillofacial Surgery, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
This study is intended to review the cephalometric data pertaining to the diverse Indian populace through a systematic literature survey. To conduct a systematic review of literature, an electronic search was done on Medline, Embase, and Central databases. The available data were categorized based on the existing five geographic locations of the country (north, south, east, west, and central India) and analyzed.
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