The Freiburg tension plate was used with Göttingen minipigs not particularly to determine the clinical relevance but rather to facilitate animal experiments with the minipig which are impossible with splints or wire. Our studies showed that the AO-mandibular-DC plates with 45 degrees arrangement of apertures used in the clinical field are also suitable for fragment stabilization with minipigs, even though the masticatory force is considerably greater than with humans. A functionally stable osteosynthesis was achieved in animal experiments, whereby the masticatory function of the minipigs was not disturbed. The fractures healed without complications.
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Proc Natl Acad Sci U S A
January 2025
Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311113, China.
Joining heterogeneous materials in engineered structures remains a significant challenge due to stress concentration at interfaces, which often leads to unexpected failures. Investigating the complex, multiscale-graded structures found in animal tissue provides valuable insights that can help address this challenge. The human meniscus root-bone interface is an exemplary model, renowned for its exceptional fatigue resistance, toughness, and interfacial adhesion properties throughout its lifespan.
View Article and Find Full Text PDFAnimal Model Exp Med
January 2025
Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.
Background: Subcortical ischemic vascular dementia (SIVD) is a common subtype of vascular dementia. Currently, the bilateral common carotid artery stenosis (BCAS) mouse model is the most suitable SIVD rodent model. In this study, we investigated the functional and structural impairments in the hippocampus 1 month after BCAS.
View Article and Find Full Text PDFMol Cell Biochem
January 2025
Department of Cardiology, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory, Disease, Guangzhou Institute of Cardiovascular Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, Guangdong, China.
Increased activity of acid sphingomyelinase (ASMase) has been linked to diabetes and organ fibrosis. Nevertheless, the precise influence of ASMase on diabetic myocardial fibrosis and the corresponding molecular mechanisms remain elusive. In this study, we aim to elucidate whether ASMase contributes to diabetic myocardial fibrosis through the phosphorylation mediated by MAPK, thereby culminating in the development of diabetic cardiomyopathy (DCM).
View Article and Find Full Text PDFActa Parasitol
January 2025
Faculty of Veterinary Medicine, Department of Parasitology, Kirikkale University, Kirikkale, 71450, Türkiye.
Purpose: In the present study, the effects of leaf and rhizome extracts of Arum rupicola Boiss rupicola were searched on the infective stage Toxocara canis larvae (L3) in the experimentally infected mice.
Methods: Four-six week-old male BALB/c mice were divided into eight groups (G1-8, each group consisted of 7 mice), and they were infected orally with 500 T. canis eggs with L3.
Drug Deliv Transl Res
January 2025
Pharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
Liver fibrosis is still a serious health concern worldwide, and there is increasing interest in mesenchymal stem cells (MSCs) with tremendous potential for treating this disease because of their regenerative and paracrine effects. Recently, many researches have focused on using the released exosomes (EXOs) from stem cells to treat liver fibrosis rather than using parent stem cells themselves. MSC-derived EXOs (MSC-EXOs) have demonstrated favourable outcomes similar to cell treatment in terms of regenerative, immunomodulatory, anti-apoptotic, anti-oxidant, anti-necroptotic, anti-inflammatory and anti-fibrotic actions in several models of liver fibrosis.
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