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Yes-associated protein 1 is essential for maintaining lactation via regulating mammary epithelial cell dynamics and secretion capacity.
Int J Biol Macromol
December 2024
Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China; Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China; Shenzhen Institute of Nutrition and Health, Huazhong Agricultural University, Shenzhen 518038, China; National Center for International Research on Animal Genetics, Breeding and Reproduction, Frontiers Science Center for Animal Breeding and Sustainable Production, Huazhong Agricultural University, Wuhan 430070, China. Electronic address:
Article Synopsis
- Understanding the role of Yes-associated protein 1 (YAP1) is essential for improving milk production in mammals, as it impacts mammary epithelial cell function during both pregnancy and lactation.
- YAP1 is highly expressed in the mammary glands of various species, especially in the alveoli during gestation and lactation, and its inhibition negatively affects milk yield and mammary gland structure in mice.
- Through its regulation of cellular processes, YAP1 interacts with hormones like Prolactin to enhance cell growth and milk components, while being inhibited by Melatonin, highlighting its critical role in lactation.
The potential therapeutic role of melatonin in organ fibrosis: a comprehensive review.
Front Med (Lausanne)
December 2024
Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China.
Organ fibrosis is a pathological process characterized by the inability of normal tissue cells to regenerate sufficiently to meet the dynamic repair demands of chronic injury, resulting in excessive extracellular matrix deposition and ultimately leading to organ dysfunction. Despite the increasing depth of research in the field of organ fibrosis and a more comprehensive understanding of its pathogenesis, effective treatments for fibrosis-related diseases are still lacking. Melatonin, a neuroendocrine hormone synthesized by the pineal gland, plays a crucial role in regulating biological rhythms, sleep, and antioxidant defenses.
View Article and Find Full Text PDFMelatonin-Mediated Modulation of Grapevine Resistance Physiology, Endogenous Hormonal Dynamics, and Fruit Quality Under Varying Irrigation Amounts.
Int J Mol Sci
December 2024
College of Horticulture, Gansu Agricultural University, Lanzhou 730070, China.
Grapevine, as a globally significant economic fruit tree, is highly sensitive to water stress, which not only damages its growth but also affects the formation of fruit quality. Melatonin (MT), acting as a signaling molecule, plays a crucial role in plant stress responses. However, the regulatory mechanisms of MT on grape leaf physiological characteristics and fruit quality under different irrigation amounts have not been fully elucidated.
View Article and Find Full Text PDFExploring the DPP IV inhibitory potential: molecular docking and dynamic simulations of pyridine-3-carboxylic acid and pyrrolidine-2-carboxylic acid analogs.
J Biomol Struct Dyn
December 2024
Department of Pharmaceutical Chemistry, Dr. D. Y. Patil Institute of Pharmaceutical Science and Research, affiliated to SPPU, Pune, India.
Diabetes mellitus remains a global challenge, with Type 2 Diabetes Mellitus (T2DM) prevalence increasing from 4% to 6.4% in the past 30 years. Presently oral hypoglycaemic agents like GLP-1 agonists, biguanides, sulphonylureas, glinides, and thiazolidinediones are employed in clinical practice.
View Article and Find Full Text PDFFluorometric detection and analog discrimination of melatonin by amide naphthotube-based indicator displacement assays.
Spectrochim Acta A Mol Biomol Spectrosc
November 2024
School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang 421001, China. Electronic address:
Melatonin, a hormone synthesized by the pineal gland, is renowned for its pivotal role in governing circadian rhythms and its promising therapeutic attributes encompassing anti-inflammatory, anti-aging, and cancer-preventative properties. Nevertheless, the improper utilization of melatonin may lead to health hazards, highlighting the critical necessity for accurate detection of melatonin in pharmaceutical or biological samples. Furthermore, melatonin metabolites exhibit analogous chemical structures yet divergent pathophysiological functions, emphasizing the significance of distinguishing between these analogs.
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