Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Participation of COX2/mPGES1/PGE2 in mouse and human endometrial stromal decidualization.
BMC Vet Res
January 2025
Division of Oncology, Department of Clinical Sciences, Lund University, Lund, 22381, Sweden.
Background: Prostaglandin E2 (PGE2) is vital for embryo implantation and decidualization. Whether COX2/mPGES1/PGE2 pathway is essential for mouse and human decidualization remains unclear.
Results: This study showed that mPGES1 was highly expressed in the mouse uterus's subluminal stromal cells at the implantation site.
Investigation of potential toxic effects of nano- and microplastics on human endometrial stromal cells.
Reprod Toxicol
January 2025
Institute of Women's Life Medical Science, Yonsei University College of Medicine, Seoul, Korea; Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Nanoplastics (NPs) and microplastics (MPs) have become a global concern in recent years. Most current research on the impact of plastics on obstetrics has focused on their accumulation in specific tissues in animal models and the disease-causing potential of MPs. However, there is a relative lack of research on the cellular changes caused by the accumulation of MPs.
View Article and Find Full Text PDFBackground Embryo implantation and early survival in a synchronized, receptive endometrium are critical for establishing a successful pregnancy, but uterine pathologies can present challenges to reproductive success by significantly impacting this complex process. Objectives The purpose of this review is to analyze the impact of uterine pathologies on embryo implantation, early embryo survival, and finally on the development of infertility, with references to reproductive outcomes and the main evidence related to therapeutic strategies. Methods The relevant publications were identified after queries of the following sources: PubMed, Google Scholar, Web of Science, and publishers' databases, complemented by a cross-check of the reference lists.
View Article and Find Full Text PDFUterine organoids reveal insights into epithelial specification and plasticity in development and disease.
Proc Natl Acad Sci U S A
February 2025
Department of Obstetrics, Gynecology, and Women's Health, University of Missouri, Columbia, MO 65211.
Understanding how epithelial cells in the female reproductive tract (FRT) differentiate is crucial for reproductive health, yet the underlying mechanisms remain poorly defined. At birth, FRT epithelium is highly malleable, allowing differentiation into various epithelial types, but the regulatory pathways guiding these early cell fate decisions are unclear. Here, we use neonatal mouse endometrial organoids and assembloid coculture models to investigate how innate cellular plasticity and external mesenchymal signals influence epithelial differentiation.
View Article and Find Full Text PDFComprehensive analysis of ceRNA Networks in UCEC: Prognostic and therapeutic implications.
PLoS One
January 2025
Department of Reproductive Medicine, Guangzhou Women and Children's Medical center Liuzhou Hospital, Liuzhou, Guangxi, China.
Endometrial cancer (UCEC) is the most prevalent gynecological malignancy in high-income countries, and its incidence is rising globally. Although early-stage UCEC can be treated with surgery, advanced cases have a poor prognosis, highlighting the need for effective molecular biomarkers to improve diagnosis and prognosis. In this study, we analyzed mRNA and miRNA sequencing data from UCEC tissues and adjacent non-cancerous tissues from the TCGA database.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!