Freshly mixed, unset zinc-free and zinc-containing analgam was implanted in the right tibia of 32 rats. Half of the specimens were examined by the light microscope and the other half by the scanning electron microscope and x-ray microprobe analysis. It was found that amalgam is well tolerated by the rat osseous tissue, and there were no histologic reaction differences between zinc and zinc free amalgam. The surfaces of the implants were covered by an organic film at 3 weeks and with bone at later intervals. Very little corrosion products containing sulfur were observed on the amalgam surface at all intervals. Bone adjacent to the amalgam contained tin and sulfur irrespective of the presence of zinc in the alloy, indicating outward migration of specific components of the alloy.
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