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Efn1 and Efn2 are extracellular 5'-nucleotidases induced during the fission yeast response to phosphate starvation.
mBio
January 2025
Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Unlabelled: The fission yeast regulon genes , , and -encoding a cell surface-associated acid phosphatase (Pho1), a plasma membrane inorganic phosphate transporter (Pho84), and a plasma membrane glycerophosphocholine transporter (Tgp1)-are strongly upregulated in response to acute phosphate starvation, as are the and genes that encode putative 5'-nucleotidase paralogs of the binuclear metallophosphoesterase enzyme superfamily. Via proteomic analysis of the medium harvested from phosphate-replete and phosphate-starved fission yeast, we define a starvation secretome that includes SPBPB2B2.06c (renamed Efn1, for xtracellular ive-prime ucleotidase), SPAC1039.
View Article and Find Full Text PDFRetinoic acid-induced alterations enhance eATP-mediated anti-cancer effects in glioma cells: Implications for P2X7 receptor variants as key players.
Biochim Biophys Acta Mol Basis Dis
December 2024
Department of Biochemistry, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University in Torun, Lwowska 1, 87-100 Toruń, Poland. Electronic address:
Retinoic acid (RA) is a small, lipophilic molecule that inhibits cell proliferation and induces differentiation through activation of a family of nuclear receptors (RARs). The therapeutic potential of RA in the treatment of glioma was first evaluated two decades ago, but these attempts were considered not conclusive. Based on the complexity of tumor microenvironment and the role of purinergic signals within TME, we aimed to support RA-induced alterations in glioma cells with extracellular ATP.
View Article and Find Full Text PDFThe metabolic engineering of Escherichia coli for the high-yield production of hypoxanthine.
Microb Cell Fact
November 2024
College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457, P. R. China.
Background: Hypoxanthine, prevalent in animals and plants, is used in the production of food additives, nucleoside antiviral drugs, and disease diagnosis. Current biological fermentation methods synthesize quantities insufficient to meet industrial demands. Therefore, this study aimed to develop a strain capable of industrial-scale production of hypoxanthine.
View Article and Find Full Text PDFElevated glucose levels increase vascular calcification risk by disrupting extracellular pyrophosphate metabolism.
Cardiovasc Diabetol
November 2024
Center for Research in Molecular Medicine and Chronic Diseases (CiMUS). Campus Vida, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain.
Article Synopsis
- - The study investigates how high glucose levels in diabetic conditions affect the metabolism of pyrophosphate, a natural inhibitor of vascular calcification, which plays a critical role in cardiovascular diseases associated with diabetes.
- - Using various experimental methods on rat and human cells, the research found that elevated glucose significantly lowers the levels of extracellular pyrophosphate and alters the activity of specific enzymes involved in its metabolism, contributing to vascular calcification.
- - Key findings include a decrease in ectonucleotide pyrophosphatase/phosphodiesterase 1 activity and an increase in ectonucleoside triphosphate diphosphohydrolase 1, leading to a harmful imbalance in the pyrophosphate/phosphate ratio, which further promotes
[Molecular mechanism of high-altitude hypoxia-induced lipid metabolism disorder in mouse spleen tissue].
Nan Fang Yi Ke Da Xue Xue Bao
October 2024
College of Medicine of Qinghai University, Xining 810016, China.
Objective: To investigate the molecular mechanism of lipid metabolism disorder in mouse spleen tissues due to high-altitude hypoxia.
Methods: Ten C57BL/6 male mice were randomly divided into normoxia group (maintained at an altitude of 400 m) and high-altitude hypoxia group (maintained at 4200 m) for 30 days (=5). Lipidomics and metabolomics analyses of the spleen tissue of the mice were conducted using liquid chromatography-mass spectrometry (LC-MS) to identify the differential metabolites, which were further analyzed by KEGG enrichment and pathway analyses, and the differential genes were screened through transcriptome sequencing.
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