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Clinical Outcomes after Revascularization in Patients with Chronic Limb-Threatening Ischemia.
Ann Vasc Dis
January 2025
Department of Vascular Surgery, Aichi Medical University, Nagakute, Aichi, Japan.
Chronic limb-threatening ischemia (CLTI) occurs in the advanced stage of peripheral artery disease and is associated with high risks of mortality and amputation. Universal management strategies are not always applicable, owing to population diversity, and the Western trials may not be applicable to Japanese patients, owing to differences in demographics and clinical profiles. This paper examines the outcomes of revascularization in Japanese CLTI patients and emphasizes the benefits of tailored management.
View Article and Find Full Text PDFThe Efficacy of Zinc Gluconate Supplementation in the Improvement of Malnutrition Indices and Skin Abnormalities in Hemodialysis Patients: A Randomized Clinical Trial.
Int J Prev Med
November 2024
Nutrition and Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Article Synopsis
- Hemodialysis patients often face issues like malnutrition and skin problems, leading researchers to investigate whether zinc supplementation could help improve these conditions.
- In a double-blind study with 87 participants, those receiving zinc gluconate showed increased appetite and reduced skin itching after 12 weeks, while no major side effects were reported.
- However, the supplementation did not significantly affect body composition, strength, or other skin abnormalities compared to the placebo group.
Managing Zinc Supplementation in Hemodialysis Patients: Balancing and Preventing Deficiencies in Serum Copper and Zinc Levels with and Without HIF-PH Inhibitors.
Nutrients
November 2024
Dialysis Center, Tesseikai Neurosurgical Hospital, 28-1 Nakanohonmachi, Shijonawate 575-8511, Japan.
Background/objectives: Zinc supplementation induces metallothionein, leading to reduced serum copper levels. Conversely, serum copper concentrations tend to rise with the use of HIF-PH inhibitors.
Methods: To establish a safe level of zinc supplementation that avoids copper deficiency, serum copper and zinc concentrations measured every three months were retrospectively analyzed over five years in 50 patients undergoing hemodialysis.
Bacterial Cellulose/Polyelectrolyte Complex Hydrogel Separator with Thermal and Dimensional Stabilities for Dendrite Suppression in Zinc Ion Battery.
ACS Omega
November 2024
Department of Materials Science, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Article Synopsis
- In this study, BC/PEC composite hydrogels were created for use as an electrode separator by blending bacterial cellulose (BC) with a polyelectrolyte complex (PEC) for enhanced properties.
- The resulting hydrogel was improved in mechanical strength and thermal stability by incorporating a cross-linking agent, glutaraldehyde, into the BC framework and controlling the formation of the PEC hydrogel.
- The BC-GA/PEC composite demonstrated lower electrolyte permeability and effective charge-discharge cycling performance in zinc batteries, showing less corrosion on the zinc anode and a reduction in dendrite growth, indicating its potential as a superior alternative to traditional liquid electrolyte separators.
Association between Serum Zinc and All-Cause Mortality in Patients Undergoing Maintenance Hemodialysis: The Osaka Dialysis Complication Study (ODCS).
Nutrients
September 2024
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka Metropolitan University Graduate School of Medicine, Osaka 545-8585, Japan.
Article Synopsis
- Zinc deficiency is common in hemodialysis patients, but its link to mortality is unclear; this study aimed to investigate the relationship between serum zinc levels and all-cause mortality in these individuals.
- In a 5-year cohort study involving 1,662 hemodialysis patients, lower serum zinc levels were associated with a higher risk of death, especially in patients with low serum albumin levels, even after accounting for other factors.
- The findings suggest that among hemodialysis patients with low serum albumin, maintaining higher serum zinc levels may be important for reducing mortality risk.
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