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Ten years of the immunogenetics laboratory performance assessment programme and its impact on the donor and transplant network.
Biomedica
December 2024
Grupo Red de Donación y Trasplantes, Instituto Nacional de Salud, Bogotá, D. C., Colombia.
Introduction. The use of immunological tests before solid organ transplantation is essential to reduce the risk of rejection and post-transplant complications. Therefore, quality control systems in laboratories performing them are necessary for clinical practice.
View Article and Find Full Text PDFAssociation study of the HLA class I system with psoriatic arthritis in Southern Tunisia: a case-control study.
Clin Rheumatol
February 2025
Immunology and Histocompatibility Department, Hedi Chaker University Hospital, Sfax, Tunisia.
Article Synopsis
- Psoriatic arthritis (PsA) is a complex inflammatory condition influenced by genetic and environmental factors; this study investigates how specific HLA alleles relate to PsA in Southern Tunisia.
- A case-control study involving 48 PsA patients and 123 controls found strong associations between HLA-B27 and HLA-C*06 with the disease, particularly in individuals homozygous for HLA-C*06.
- Certain HLA alleles were notably linked to specific disease characteristics, such as HLA-B27 with familial PsA and various HLA types associated with other manifestations like cervical spine involvement and uveitis.
[Identification of Predictive Biomarkers for Immune Checkpoint Inhibitors by Immunogenomics].
Gan To Kagaku Ryoho
September 2024
Dept. of Urology, Osaka University Graduate School of Medicine.
The research field of immunogenomics, which elucidates the detail information of immune cells and HLA based on genomic information, is becoming an essential field for understanding the pathology not only in cancer field but also in autoimmune diseases, organ transplantation, and other areas where immune responses are involved. With the comprehensive understanding of T cell receptors, B cell receptors, cancer mutational profiling, we believe that immunogenomics will greatly contribute to personalized medicine by elucidating various pathological and immunological conditions. In this article, we introduce specific examples of immunogenomics in cancer field for better understanding Immunogenomics.
View Article and Find Full Text PDFEffect of immunogenetics polymorphism and expression on direct-acting antiviral drug response in chronic hepatitis C.
Clin Exp Med
August 2024
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
The prevalence of HCV infection in Egypt has decreased following the introduction of direct-acting antiviral therapy. However, treatment response is influenced by various factors, particularly host immunogenetics such as IL-28B and FOXP3 polymorphisms. The current study examined the impact of SNPs in the FOXP3 gene promoter region on HCV-infected Egyptian patients, along with SNPs in the IL28B gene.
View Article and Find Full Text PDF[RECOMMENDATION FOR ITCH ASSESSMENT FROM THE ATOPIC ITCH CONSENSUS MEETING (AICOM)].
Arerugi
March 2024
Department of Dermatology, Graduate School of Biomedical Sciences, Nagasaki University.
Background: Itch is the most troublesome symptom of atopic dermatitis, and it is important to assess it appropriately for optimal treatment. We discussed issues regarding itch and the most appropriate methods of assessment at the Atopic Itch Consensus Meeting (AICOM), attended by physicians and researchers with expertise in itch treatment and research.
Methods: The AICOM participants prepared a draft consensus statement that addressed the most appropriate itch assessment methods for age groups <2 years, 2-6 years, 7-14 years, and ≥15 years.
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