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From smog to scarred hearts: unmasking the detrimental impact of air pollution on myocardial ischemia-reperfusion injury.
Cell Mol Life Sci
January 2025
Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Air pollution is a global environmental health hazard associated with elevated cardiovascular morbidity and mortality. Emerging evidence suggests that exposure to various air pollutants, specifically particulate matter (PM), ultrafine particulate matter (UFPM), and diesel exhaust particles, may exacerbate myocardial ischemia-reperfusion (I/R) injury. PM exposure can directly impair cardiomyocyte survival under ischemic conditions by inducing inflammation, oxidative stress, apoptosis, and dysregulation of non-coding RNAs.
View Article and Find Full Text PDFPomegranate as a natural remedy for gastric ulcers prevention: a review of its gastroprotective mechanisms and pharmacological benefits.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 1988873554, Iran.
Gastric ulcers (GUs) represent a common gastrointestinal disorder characterized by mucosal damage and inflammation, often precipitated by factors such as Helicobacter pylori infection and the consumption of COX inhibitors. This comprehensive review investigates the role of oxidative stress and inflammation in the pathogenesis of GUs and assesses the potential therapeutic effects of Punica granatum (pomegranate, Pg) supplementation. Utilizing a series of experimental models, including indomethacin, aspirin, and alcohol-induced ulcers, we demonstrate that Pg extracts possess significant gastroprotective properties.
View Article and Find Full Text PDFComparative Analysis of Caco-2 Cells and Human Jejunal and Duodenal Enteroid-Derived Cells in Gel- and Membrane-Based Barrier Models of Intestinal Permeability.
Toxicol Sci
January 2025
Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas, 77843, USA.
Intestinal absorption is a key toxicokinetics parameter. While the colon carcinoma cell line Caco-2 is the most used in vitro model to estimate human drug absorption, models representing other intestinal segments are developed. We characterized the morphology, tissue-specific markers and functionality of three human intestinal cell types: Caco-2, primary human enteroid-derived cells from jejunum (J2), and duodenum (D109) when cultured in the OrganoPlate® 3-lane 40 microphysiological system (MPS) or static 24-well Transwells™.
View Article and Find Full Text PDFMolecular miscibility of ASD blend components: an evaluation of (the added value of) solid state NMR spectroscopy and relaxometry.
J Pharm Sci
January 2025
Drug Delivery and Disposition, KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Campus Gasthuisberg ON2, Herestraat 49 b921, 3000 Leuven, Belgium. Electronic address:
In order to evaluate the stability of an amorphous solid dispersion (ASD) it is crucial to be able to accurately determine whether the ASD components are homogeneously mixed or not. Several solid-state analysis techniques are at the disposal of the formulation scientist, such as for example modulated differential scanning calorimetry (mDSC) and solid-state nuclear magnetic resonance spectroscopy (ssNMR). ssNMR is a robust, versatile, and accurate analysis technique with a large number of application possibilities.
View Article and Find Full Text PDFIndomethacin-Induced Gastric Ulcer in Rats: Gastroprotectivity of in Water.
Pharmaceuticals (Basel)
December 2024
Department of Pathology, Faculty of Veterinary Medicine, Ataturk University, Erzurum 25240, Türkiye.
The plant . is employed in both raw and cooked forms for the treatment of gastric diseases, as an expectorant, and for the treatment of warts and the enhancement of urine. A review of the scientific literature revealed no studies investigating the effect of (MN) water extract on gastric diseases.
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