Trabecular meshwork and iris were studied by light and electron microscopy in a 40-year-old female with pigmentary glaucoma. Elevation of the intraocular pressure was most likely due to closure the intertrabecular space by pigment granules and large cells resembling clump cells, fibrous substances, and hypertrophied endothelial cells of the trabecular sheet, which had phagocytized pigment granules.
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Investigating the miRNA-mRNA interactome of human trabecular meshwork cells treated with TGF-β1 provides insights into the pathogenesis of pseudoexfoliation glaucoma.
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