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The current state of mental health treatment for individuals diagnosed with major depressive disorder leaves billions of individuals with first-line therapies that are ineffective or burdened with undesirable side effects. One major obstacle is that distinct pathologies may currently be diagnosed as the same disease and prescribed the same treatments. The key to developing antidepressants with ubiquitous efficacy is to first identify a strategy to differentiate between heterogeneous conditions.
View Article and Find Full Text PDFThe experiences of attending an international veteran sporting competition and preparatory camp for Team Ukraine during the Russo-Ukrainian conflict.
Front Sports Act Living
December 2024
BRAVO VICTOR, London, United Kingdom.
Introduction: This article offers unique insight into Team Ukraine's experiences of attending an international sporting event for veterans living with disability and injured active-duty personnel (the United States' Department of Defense Warrior Games, "The Games") and a 5-week preparatory camp in the United Kingdom (UK).
Methods: A survey gathered qualitative data at three time points: during the second and final week of training camp, and the in the two weeks immediately following participation at The Games. Forty-four out of 55 members of Team Ukraine (including veterans, active-duty personnel, support staff, and family members) provided responses in Survey 1, 20 in Survey 2, and 18 in Survey 3.
Glucagon-like peptide-1 receptor agonists and upper endoscopy: a real-world experience.
Obesity (Silver Spring)
January 2025
Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Objective: Increased use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) has raised safety concerns during endoscopy due to their mechanism of delaying gastric emptying. This study aims to evaluate the impact of GLP-1RAs on technical success and safety of esophagogastroduodenoscopy (EGD).
Methods: This was a retrospective study of bariatric patients who underwent EGD between January 2022 and December 2023.
Alström syndrome: the journey to diagnosis.
Orphanet J Rare Dis
January 2025
Department of Diabetes, Endocrinology and Metabolism, University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital, Birmingham, B15 2TH, UK.
Background: Alström syndrome (AS) is a recessively inherited genetic condition which is ultra-rare and extremely complex. Symptoms include retinal dystrophy, nystagmus, photophobia, hearing loss, obesity, insulin resistance, diabetes and cardiomyopathy. The condition is progressive, but it is important to note that not all the complications associated with AS occur in everyone affected.
View Article and Find Full Text PDFLiving with Pediatric Coeliac Disease: Lessons for Health Service Delivery.
Dig Dis Sci
January 2025
Department of Paediatric Gastroenterology, Hepatology and Liver Transplant, Queensland Children's Hospital, Graham St, South Brisbane, 4101, Australia.
Background: Coeliac Disease (CD) affects up to 1.4% of children worldwide, with a rising global incidence. A less typical clinical presentation and the need for a life-long gluten exclusion diet raise challenges for diagnosis, management, and healthcare delivery with considerable impacts for CD patients and families as well as clinical services.
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