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Human embryo implantation: The complex interplay between endometrial receptivity and the microbiome.
J Reprod Immunol
January 2025
Chengdu Fifth People's Hospital, (School of Medical and Life Sciences/Affiliated Fifth People's Hospital, Chengdu University of Traditional Chinese Medicine), Chengdu, China. Electronic address:
The endometrial and vaginal microbiota have co-evolved with the reproductive tract and play a key role in both health and disease. However, the difference between endometrial and vaginal microbiota, as well as their association with reproductive outcomes in women undergoing frozen embryo transfer, remains unclear. 120 women who underwent in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) and whole embryo freezing were enrolled.
View Article and Find Full Text PDFHow do trees fail in intraspecific competition? A test for the roles of non-structural carbohydrates and stoichiometries in Pinus massoniana.
Plant Physiol Biochem
January 2025
College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, China. Electronic address:
Competition is ubiquitous and an important driver of tree mortality. Non-structural carbohydrates (NSCs, including soluble sugars and starch) and C-N-P stoichiometries are affected by the competitive status of trees and, in turn, physiologically determine tree growth and survival in competition. However, the physiological mechanisms behind tree mortality caused by intraspecific competition remain unclear.
View Article and Find Full Text PDFSpecific Immune Responses and Oncolytic Effects Induced by EBV LMP2A-Armed Modified Ankara-Vaccinia Virus Vectored Vaccines in Nasopharyngeal Cancer.
Pharmaceutics
January 2025
NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China.
Background: The Epstein-Barr virus (EBV) is intricately linked to a range of human malignancies, with EBV latent membrane protein 2A (LMP2A) emerging as a potential target antigen for immunotherapeutic strategies in the treatment of nasopharyngeal carcinoma (NPC).
Methods: The modified vaccinia virus Ankara (MVA) is universally used in vector vaccine research because of its excellent safety profile and highly efficient recombinant gene expression. Here, we constructed a novel MVA-LMP2A recombinant virus and investigated its specific immune response induction and oncolytic effect.
Importance of OsRac1 in Signalling of Pigm-1 Mediated Resistance to Rice Blast Disease.
Plants (Basel)
January 2025
College of Agriculture and Plant Immunity Center, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
In rice, leucine-rich repeat nucleotide-binding site (NLR) proteins are pivotal immune receptors in combating -triggered rice blast. However, the precise molecular mechanism underlying how NLR proteins regulate downstream signalling remains elusive due to the lack of knowledge regarding their direct downstream targets. The NLR protein Pigm-1 was cloned from Shuangkang 77009 in our laboratory.
View Article and Find Full Text PDFStructural Characterizations and Biological Evaluation of a Natural Polysaccharide from Branches of Abel.
Pharmaceuticals (Basel)
January 2025
College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China.
Background: Abel () is widely cultivated and serves as an important source of edible oil. Yet, during oil production, pruned branches generate significant waste and contribute to environmental pollution.
Objectives: In this work, we obtain a natural polysaccharide from the branches of and optimize its extraction using Box-Behnken design (BBD), which is a statistical method commonly used in response surface methodology.
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