Effect of hordox on activity of the kallikrein-prekallikrein system was studied in blood plasma of patients with stenosis of abdominal aorta during the reconstructive operation and in patients with septic complications after the open-heart operation. These impairments were accompanied by a distinct increase in kallikrein activity with simultaneous decrease in prekallikrein content, suggesting activation of the kininogenase system; the kallikrein activity was normalized in patients treated with the inhibitor. The highest efficiency of the inhibitor was observed in patients with stenosis of abdominal aorta; in patients with septic complications it was 4-fold less effective. The data obtained suggest that inhibition of the blood plasma kininogenase system correlates with restoration in these patients. The results, obtained in study of the inhibitor efficiency in vitro and in vivo, may be used for calculation of therapeutic doses of the proteinase inhibitors.
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