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Modified Cortisol Circadian Rhythm: The Hidden Toll of Night-Shift Work.
Int J Mol Sci
February 2025
Section of Endocrinology and Metabolic Diseases, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
The circadian rhythm of cortisol, a key hormone essential for maintaining metabolic balance and stress homeostasis, is profoundly disrupted by night-shift work. This narrative review examines the physiological mechanisms underlying cortisol regulation, the effects of shift work on its circadian rhythm, the associated health risks, and potential mitigation strategies. Night-shift work alters the natural secretion pattern of cortisol, leading to dysregulation of the hypothalamic-pituitary-adrenal axis, which in turn can contribute to metabolic disorders, cardiovascular diseases, and impaired cognitive function.
View Article and Find Full Text PDFPrevalence and Correlates of Osteoporosis and Metabolic Syndrome Among Patients With Chronic Obstructive Pulmonary Disease at a Rural Tertiary Healthcare Center in India.
Cureus
February 2025
Department of Respiratory Medicine, Uttar Pradesh University of Medical Sciences, Etawah, IND.
Background Chronic obstructive pulmonary disease (COPD) results from chronic inflammation triggered by various risk factors. This inflammation can also impact other organ systems. COPD patients often have comorbidities such as osteoporosis and metabolic syndrome.
View Article and Find Full Text PDFA Severe Manic Episode Induced by Corticosteroid Treatment in a Patient With Subthreshold Bipolar Disorder.
Cureus
February 2025
Psychiatry, Hatsuishi Hospital, Kashiwa, JPN.
Corticosteroid treatment sometimes causes psychiatric side effects such as mania, depression, and psychosis. It is believed that exogenous corticosteroids lead to dysregulation of corticosteroid signaling and neurotransmitters in a dose-dependent manner. Therefore, the administration of corticosteroids is at risk of worsening bipolar disorder.
View Article and Find Full Text PDFSupratherapeutic Inhaled Corticosteroid Use in Patients Initiating on Biologic Therapies for Severe Asthma: A Nationwide Cohort Study.
Lung
March 2025
Department of Respiratory Medicine, Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark.
Background: In severe asthma, intensive ("supratherapeutic") doses of inhaled corticosteroids (ICS) are often used. The prevalence of supratherapeutic ICS use and its impact on corticosteroid-related comorbidities is poorly understood. We aimed to describe the prevalence of supratherapeutic ICS use in severe asthma, its relation to corticosteroid-related comorbidities, and changes in prescribed and redeemed ICS dose after 12 months of biologic therapy.
View Article and Find Full Text PDFCiprofloxacin-Induced Leukocytoclastic Vasculitis.
Cureus
February 2025
Cardiology Department, Unidade Local De Saúde São João, Porto, PRT.
Ciprofloxacin is a widely used empiric antibiotic that may cause adverse reactions, including leukocytoclastic vasculitis (LCV). We present the case of a 51-year-old woman diagnosed with pyelonephritis, who developed cutaneous vasculitic lesions one day after ciprofloxacin administration. The differential diagnosis was broad and included autoimmune diseases, which were ruled out through extensive testing.
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