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Relevance of the common-sense model for people living with a genetic predisposition for breast and ovarian cancer.
Br J Health Psychol
February 2025
SCALab - Cognitives and Affectives Sciences, National Center of Scientific Research (CNRS UMR 9193), University of Lille, Lille, France.
Objectives: BRCA1/2 pathogenic variants have been associated with an increased risk for breast, ovarian, pancreatic, prostate cancer as well as melanoma. The present research uses the Leventhal's common-sense model of self-regulation (CSM), a theoretical framework highlighting the role of mental representations on responses to a health-threat. We aim at understanding the personal meaning and representation of living with an hereditary breast and ovarian cancer predisposition.
View Article and Find Full Text PDFCase report: A case study of neoadjuvant immunochemotherapy for locally advanced esophageal squamous carcinoma.
Front Oncol
July 2024
Department of Thoracic Surgery, Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, China.
In locally advanced esophageal cancer, the controversy over the two traditional treatment modalities, neoadjuvant radiotherapy and neoadjuvant chemotherapy, has been unending and also challenged by the addition of neoadjuvant immunotherapy. Neoadjuvant immunotherapy has led to an increasing diversity of neoadjuvant combination treatment modalities, among which neoadjuvant immunochemotherapy has emerged, with current clinical studies initially demonstrating its efficacy and safety. We report a case of a patient with locally advanced esophageal cancer who underwent two cycles of neoadjuvant immunochemotherapy and successful surgery and achieved a pathological complete response (pCR).
View Article and Find Full Text PDFSustained systemic inflammation increases autophagy and induces EMT/fibrotic changes in mouse liver cells: Protection by melatonin.
Cell Signal
January 2023
Department of Physiology, University of Calcutta, Kolkata, West Bengal, India; Centre for Research in Nanoscience and Nanotechnology (CRNN), University of Calcutta, JD-2, Salt Lake, Sector III, Kolkata 700098, India. Electronic address:
The unending lifestyle stressors along with genetic predisposition, environmental factors and infections have pushed the immune system into a state of constant activity, leading to unresolved inflammation and increased vulnerability to chronic diseases. Liver fibrosis, an early-stage liver condition that increases the risk of developing liver diseases like cirrhosis and hepatocellular carcinoma, is among the various diseases linked to inflammation that dominate worldwide morbidity and mortality. We developed a mouse model with low-grade lipopolysaccharide (LPS) exposure that shows hepatic damage and a pro-inflammatory condition in the liver.
View Article and Find Full Text PDFLung cancer screening: An unending tale.
J Cancer Res Ther
March 2022
Department of Radiation Oncology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
The year 2020 will go down in various online archives as unbelievable, unreal, seemingly unending, and brimming with unknowns. Let's face it. How many times this year have you said, "I don't know" to yourself or to others? Let me offer a litany of situations.
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