Cholesterol and analogues of cholesterol bearing shorter side chains were incorporated into rat platelet membranes by incubation with sterol-rich liposomes in vitro. Cholesterol-enriched platelets showed increased aggregability to collagen compared with controls. Platelets containing the cholesterol analogues pregn-5-en-3 beta-ol and chol-5-en-3 beta-ol were even more sensitive to aggregation and could aggregate spontaneously on stirring. The size of the platelets containing pregn-5-en-3 beta-ol was markedly reduced when compared with controls in the scanning electron microscope. The results suggest that the sterol content and structure of the platelet membrane can have a critical role in maintaining the normal function of the cell.

Download full-text PDF

Source
http://dx.doi.org/10.1016/0005-2736(82)90369-8DOI Listing

Publication Analysis

Top Keywords

cholesterol analogues
12
platelets cholesterol
8
compared controls
8
pregn-5-en-3 beta-ol
8
cholesterol
5
effects vitro
4
vitro incorporation
4
incorporation cholesterol
4
cholesterol cholesterol
4
analogues rat
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!