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Chemical proteomic profiling reveals prostaglandin termination enzyme PTGR2 as a key molecular target of natural coumarin fraxetin.
Chem Commun (Camb)
January 2025
College of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China.
Natural coumarins represent a diverse group of secondary metabolites with a wide range of biological activities. However, their specific molecular targets have remained largely unexplored. Employing chemical proteomics, a comprehensive analysis of the protein targets of the natural coumarin fraxetin has been conducted.
View Article and Find Full Text PDFPlacental Proteomics Reveals an Elevated Level of Aldo-Keto Reductase 1-B1, Highlighting Its Potential Role in Spontaneous Preterm Birth.
J Proteome Res
January 2025
NCR Biotech Science Cluster, Regional Centre for Biotechnology, Faridabad 121001, India.
Preterm birth (PTB) refers to the delivery of a baby before the completion of 37 weeks of gestation. It is a significant global health issue with implications for both mothers and neonates. The placenta is a transient organ crucial in the sustenance of pregnancy until parturition; its dysfunction is associated with different adverse pregnancy outcomes, including PTB.
View Article and Find Full Text PDFMulti-sample analytical workflow for the determination of isoprostanes in oral fluid: A new tool for non-invasive evaluation of oxidative stress.
Talanta
April 2025
Sapienza University of Rome, Department of Chemistry, 00185, RM, Italy.
Oxidative stress is a pathological condition that contributes to the onset of various diseases. In this way, studying oxidative stress could lead to significant discoveries in the field of therapeutic and preventive medicine. Lipid peroxidation is the most significant event in the oxidative stress process and the gold standard biomarkers for endogenous oxidative damage to lipids are isoprostanes (IsoPs).
View Article and Find Full Text PDFSporidiobolus pararoseus polysaccharides relieve rheumatoid arthritis by regulating arachidonic acid metabolism and bone remodeling signaling pathway.
Int J Biol Macromol
November 2024
Wuxi 9(th) People's Hospital Affiliated to Soochow University, Wuxi 214062, China. Electronic address:
Rheumatoid arthritis (RA) is an autoimmune-mediated disease with the highest disability rate. Sporidiobolus pararoseus polysaccharides (SPP) have been demonstrated to have anti-rheumatoid and microbiota-modulatory effects; however, the underlying mechanisms remain unclear. This study employed collagen-induced arthritis (CIA) mice to explore the metabolic and genetic pathways.
View Article and Find Full Text PDFAdipose tissue oxylipin profile changes with subclinical ketosis and depot in postpartum dairy cows.
J Dairy Sci
January 2025
Department of Veterinary Sciences, Davis College of Agricultural Sciences and Natural Resources, Texas Tech University, Lubbock, TX 79409; School of Veterinary Medicine, Texas Tech University, Amarillo, TX 79106. Electronic address:
Lipolysis of adipose tissue is a natural occurrence during the periparturient period in dairy cows. However, when lipolysis rates exceed the capacity of other tissues to used nonesterified fatty acids, it may lead to the development of ketosis and other diseases. Additionally, PUFA can become oxidized into oxylipins, which modulate inflammation and metabolism.
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