The initial and terminal patterns of DNA replication in the chromosomes of the hybrids arising from a fusion of mouse lymphosarcoma LS/BL cells and L cells (HGPRT-) were studied. The replication of chromosomes in the hybrids compared to the parent cells was not modified by the alterations in generation time of the hybrids not by segregation of telocentric chromosomes. It can be assumed that there is a gross control system in LS/BL X L hybrids that is responsible for the patterns and timing of chromosome DNA replication and does not depend on interactions between genomes of the parent cells.
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