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Effect of methimazole treatment on Th1, Th17, and Th22 lymphocytes in pediatric Graves' disease patients.
Front Immunol
October 2024
Clinical Department of Pediatrics, Endocrinology, Diabetes with Cardiology Division, Medical University of Bialystok, Bialystok, Poland.
Graves' disease is the leading cause of autoimmune hyperthyroidism. Thyroid hormones are an essential element of the endocrine system, playing a pivotal role in the body's development, especially important in children with intensified growth. Disturbance within thyroid tissue certainly affected the whole body.
View Article and Find Full Text PDFA Multicenter, Single-Blind, Case-Control, Immunohistochemical Study of Orbital Tissue in Thyroid Eye Disease.
Thyroid
December 2022
Molecular Thyroid Research Lab, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany.
Thyroid eye disease (TED) involves several pathogenic pathways and a battery of infiltrating mononuclear cells, cytokines, and chemokines in the orbit. Revealing the main molecules, which play a major role in the pathogenesis of TED, will help developing novel treatment strategies. In a multicenter, single-blind, case-control study, 60 tissue samples were collected during orbital decompression (44 TED patients) or non-TED related oculoplastic (16 controls) surgeries.
View Article and Find Full Text PDFRegulatory B Cells Involvement in Autoimmune Phenomena Occurring in Pediatric Graves' Disease Patients.
Int J Mol Sci
October 2021
Department of Pediatrics, Endocrinology and Diabetes with a Cardiology Unit, Medical University of Bialystok, 15-274 Bialystok, Poland.
Graves's disease is the most common type of autoimmune hyperthyroidism. Numerous studies indicate different factors contributing to the onset of the disease. Despite years of research, the exact pathomechanism of Graves' disease still remains unresolved, especially in the context of immune response.
View Article and Find Full Text PDFEvaluating the Role of Circulating Dendritic Cells in Methimazole-Treated Pediatric Graves' Disease Patients.
Genes (Basel)
January 2021
Cardiology Unit, Department of Pediatrics, Endocrinology and Diabetes, Medical University of Bialystok, 15-274 Bialystok, Poland.
Graves' disease (GD) is hyperthyroidism associated with organ-specific autoimmune inflammation. GD occurs more frequently in adults than in children; however, pediatric patients are a therapeutic challenge due to cycles of remissions and relapses requiring constant monitoring at every stage of treatment administered. Dendritic cells (DCs) are considered to be a link between innate and adaptive immunity.
View Article and Find Full Text PDFHomozygous expression of the myofibrillar myopathy-associated p.W2710X filamin C variant reveals major pathomechanisms of sarcomeric lesion formation.
Acta Neuropathol Commun
September 2020
Institute for Cell Biology, Department of Molecular Cell Biology, University of Bonn, Ulrich-Haberland-Str. 61a, 53121, Bonn, Germany.
Filamin C (FLNc) is mainly expressed in striated muscle cells where it localizes to Z-discs, myotendinous junctions and intercalated discs. Recent studies have revealed numerous mutations in the FLNC gene causing familial and sporadic myopathies and cardiomyopathies with marked clinical variability. The most frequent myopathic mutation, p.
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