AI Article Synopsis
- The study used Sephadex gel column chromatography to separate substances based on their molecular weight while examining different brands of HIDA incubated in plasma.
- The results indicated that incubation in plasma did not affect dimethyl HIDA or diethyl HIDA.
- However, para-butyl HIDA showed an increased Rf value after incubation, suggesting it binds to plasma proteins unlike the other HIDA variants.
Article Abstract
By using Sephadex gel column chromatography to separate substances into their various components according to molecular weight, we have investigated the effect of incubating several "brands" of HIDA in plasma, in vitro. The results show that such incubation has no effect on either dimethyl HIDA, or diethyl HIDA, but that in the case of para-butyl HIDA, incubation in plasma increases the Rf value to that of HSA (human serum albumin). This indicates that para-butyl HIDA becomes bound to plasma proteins, in contrast to both dimethyl HIDA and diethyl HIDA.
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| http://dx.doi.org/10.1007/BF00445616 | DOI Listing |
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