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Hypoxia Activated Nitric Oxide Donor Compounds for the Prevention and Treatment of Myocardial Hypoxia-Induced Injury.
J Med Chem
January 2025
Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China.
A series of hypoxia-targeted nitric oxide donor compounds were designed and synthesized by using an ether linker to connect -methyl--nitroso--phenol and nitrobenzyl alcohols, respectively. Among them, , with acceptable pharmacokinetic parameters in mice, exhibited a high selective NO release in H9c2 cells under hypoxia and in the dissected heart tissue of the tested mice as desired. Mechanistic investigations revealed that could regulate vascular dilation and modulate proteins associated with myocardial injury both and .
View Article and Find Full Text PDFPeripheral edema induced by isosorbide mononitrate in an elderly patient: A case study of dose-related risks and drug interactions.
Eur J Clin Pharmacol
February 2025
Maliba Pharmacy College, Uka Tarsadia University Bardoli, Dist. Surat- 394350, Gujarat, India.
Adverse drug reactions (ADRs) in elderly patients are frequently attributed to age-related altered pharmacokinetics and the complexities of polypharmacy to manage multiple chronic conditions, making elderly patients more susceptible to ADRs. The following is a case report of an 80-year-old female patient with systemic symptoms of chest pain, low blood sugar, mouth ulcers, and concentrates on peripheral edema due to nitrate vasodilator isosorbide mononitrate (ISMN). She had hypertension, diabetes, ischemic heart disease, and chronic obstructive pulmonary disease (COPD).
View Article and Find Full Text PDFCan Severe Hypertriglyceridemia Cause Angina in the Absence of Significant Coronary Artery Lesions?
Eur J Case Rep Intern Med
November 2024
Faculty of Medicine, Damascus University, Damascus, Syria.
Unlabelled: Hyperlipidaemia is considered one of the most common risk factors for ischemic heart disease. Severely elevated triglyceride levels may lead to hyperviscosity which may contribute to endothelial dysfunction, tissue ischemia and chylomicronaemia. This case report features a 39-year-old, non-smoker male with a past medical history of hypertension and no family history of coronary artery disease, who presented to the clinic with angina.
View Article and Find Full Text PDFIsosorbide-Based Acrylic Pressure-Sensitive Adhesives Through UV-Cured Crosslinking with a Balance Between Adhesion and Cohesion.
Polymers (Basel)
November 2024
MOE Key Laboratory of High Performance Polymer Materials and Technology, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
The development of sustainable pressure-sensitive adhesives (PSAs) from natural biomass resources has attracted increasing attention owing to their non-toxic, biocompatible, and biodegradable features. In this study, a bio-based acrylic PSA with tunable adhesion and cohesion was synthesized by a selective chemical modification of isosorbide-5-acrylate (IA) and its copolymerization with butyl acrylate and acrylic acid through UV-curing crosslinking. During the UV-curing process, the synthesized isosorbide diacrylate ester (IDAE) served as the crosslinker, effectively improving the crosslinking degree of PSA.
View Article and Find Full Text PDFOrganic vs. inorganic nitrates: Metabolic and vascular outcomes in STZ-induced diabetes in mice.
Life Sci
December 2024
Biotechnology Center, Federal University of Paraíba, João Pessoa, Brazil. Electronic address:
Background: Diabetic animals often display dysregulated nitric oxide (NO) metabolism, contributing to vascular dysfunction. This study evaluates the metabolic and vascular effects of organic nitrate isosorbide mononitrate (ISMN) versus inorganic sodium nitrate (NaNO3) in mice with type 1 diabetes mellitus (T1DM) induced by streptozotocin (STZ).
Experimental Approach: T1DM was induced in male C57Bl6 mice with STZ ip and confirmed by fasting glucose.
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