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An improved dynamic metabolic model for application to biota.
J Environ Radioact
December 2024
"Horia Hulubei" National Institute for Physics and Nuclear Engineering, Life and Environmental Physics Department, 30 Reactorului St., Bucharest-Magurele, POB MG-6, RO-077125, Romania. Electronic address:
Any major nuclear facility must ensure the conservation of biodiversity regarding radiation protection of biota. A special concern is for tritium (H) and radiocarbon (C) transfer in wild mammals, birds and reptiles. Hydrogen and carbon are the main components of biological tissues and enter the life cycle.
View Article and Find Full Text PDFTotal Outflow of High-Density Lipoprotein-Cholesteryl Esters from Plasma Is Decreased in a Model of 3/4 Renal Mass Reduction.
Int J Mol Sci
December 2023
Department of Molecular Biology, Instituto Nacional de Cardiologia "Ignacio Chavez", Mexico City 14080, Mexico.
(1) Background: Previous studies have enriched high-density lipoproteins (HDL) using cholesteryl esters in rabbits with a three-quarter reduction in functional renal mass, suggesting that the kidneys participate in the cholesterol homeostasis of these lipoproteins. However, the possible role of the kidneys in lipoprotein metabolism is still controversial. To understand the role of the kidneys in regulating the HDL lipid content, we determined the turnover of HDL-cholesteryl esters in rabbits with a three-quarter renal mass reduction.
View Article and Find Full Text PDFAssaying the Molecular Determinants and Kinetics of RNA Pseudouridylation by H/ACA snoRNPs and Stand-Alone Pseudouridine Synthases.
Methods Mol Biol
June 2021
Department of Chemistry and Biochemistry, Alberta RNA Research and Training Institute, University of Lethbridge, Lethbridge, AB, Canada.
Posttranscriptional modifications of RNA play an important role in promoting the maturation and functional diversity of many RNA species. Accordingly, understanding the enzymes and mechanisms that underlie RNA modifications is an important aspect in advancing our knowledge of the continually expanding RNA modification field. However, of the more than 160 currently identified RNA modifications, a large portion remains without quantitative detection assays for their biochemical characterization.
View Article and Find Full Text PDFGreater early postprandial suppression of endogenous glucose production and higher initial glucose disappearance is achieved with fast-acting insulin aspart compared with insulin aspart.
Diabetes Obes Metab
July 2018
Novo Nordisk, Søborg, Denmark.
Aim: To investigate the mechanisms behind the lower postprandial glucose (PPG) concentrations achieved with fast-acting insulin aspart (faster aspart) than with insulin aspart (IAsp).
Materials And Methods: In a randomized, double-blind, crossover trial, 41 people with type 1 diabetes received identical subcutaneous single faster aspart and IAsp doses (individualized for each participant), together with a standardized mixed meal (including 75 g carbohydrate labelled with [1- C] glucose). PPG turnover was determined by the triple-tracer meal method using continuous, variable [6- H] glucose and [6,6- H ] glucose infusion.
Region-specific aging of the human brain as evidenced by neurochemical profiles measured noninvasively in the posterior cingulate cortex and the occipital lobe using H magnetic resonance spectroscopy at 7 T.
Neuroscience
June 2017
Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, 2021 6th ST SE, Minneapolis, MN 55455, United States.
The concentrations of fourteen neurochemicals associated with metabolism, neurotransmission, antioxidant capacity, and cellular structure were measured noninvasively from two distinct brain regions using H magnetic resonance spectroscopy. Seventeen young adults (age 19-22years) and sixteen cognitively normal older adults (age 70-88years) were scanned. To increase sensitivity and specificity, H magnetic resonance spectra were obtained at the ultra-high field of 7T and at ultra-short echo time.
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